Slc6a3 - solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Gene

中文名称：溶质载体家族 6 (神经递质转运蛋白，多巴胺) ，成员 3

种属: Mus musculus

同用名: DAT; Dat1

关于 Slc6a3

功能概要

该基因编码的蛋白可启动多种功能，包括多巴胺结合活动；多巴胺：钠同向转运体活性；和蛋白质 N 末端结合活性。参与多巴胺摄取；透明血管丛退化；和神经递质的摄取。作用于多个过程的上游或内部，包括多巴胺代谢过程；腺体发育；和前脉冲抑制。位于轴突和细胞表面。在泌尿生殖系统中表达；神经系统;脾;和颌下腺。用于研究 Gilles de la Tourette 综合症；注意力缺陷多动障碍;和精神分裂症。该基因的人类直系同源物与注意力缺陷多动障碍有关；尼古丁依赖；和肥胖。与人类 SLC6A3（溶质载体家族 6 成员 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including dopamine binding activity; dopamine:sodium symporter activity; and protein N-terminus binding activity. Involved in dopamine uptake; hyaloid vascular plexus regression; and neurotransmitter uptake. Acts upstream of or within several processes, including dopamine metabolic process; gland development; and prepulse inhibition. Located in axon and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]