2. Gene
  3. CPEB2 - cytoplasmic polyadenylation element binding protein 2 Gene

CPEB2 - cytoplasmic polyadenylation element binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞质聚腺苷酸化元件结合蛋白 2

种属: Homo sapiens

同用名: CPEB-2; CPE-BP2; hCPEB-2

基因 ID: 132864 | 基因类型: protein coding

关于 CPEB2

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:15,002,481-15,070,151 (from NCBI)

This gene has 8 transcripts (splice variants), 187 orthologues and 3 paralogues. Broad expression in testis (RPKM 12.0), skin (RPKM 7.9) and 24 other tissues.

功能概要

该基因编码的蛋白质与细胞质聚腺苷酸化元件结合蛋白 (CPEB) 高度相似，CPEB 是一种 mRNA 结合蛋白，可调节 mRNA 的细胞质聚腺苷酸化，作为卵子发生和精子发生中的反式因子。对小鼠中相似基因的研究表明，这种蛋白质可能在转录失活的单倍体精子细胞中发挥作用。已经描述了编码不同同种型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

CPEB2 基因产物(6)

mRNA Protein Name
NM_001177381.2 NP_001170852.1 cytoplasmic polyadenylation element-binding protein 2 isoform C
NM_001177382.2 NP_001170853.1 cytoplasmic polyadenylation element-binding protein 2 isoform D
NM_001177383.2 NP_001170854.1 cytoplasmic polyadenylation element-binding protein 2 isoform E
NM_001177384.2 NP_001170855.1 cytoplasmic polyadenylation element-binding protein 2 isoform F
NM_182485.3 NP_872291.2 cytoplasmic polyadenylation element-binding protein 2 isoform B
NM_182646.3 NP_872587.2 cytoplasmic polyadenylation element-binding protein 2 isoform A
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
18752464 GOA
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
18752464 GOA
involved in negative regulation of cytoplasmic translation IMP
IMP: 通过突变表型推断
18752464 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
20639532 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20639532 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CPEB2 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (334 - 395)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 589 a.a.
蛋白主名 其他名称

cytoplasmic polyadenylation element-binding protein 2

CPE-binding protein 2

关联疾病

疾病名称 别名
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03092 CPEB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22454 Cpeb2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28977 Cpeb2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CPEB2 VGNC VGNC:53162
Macaca mulatta CPEB2 VGNC VGNC:100212
Bos taurus CPEB2 VGNC VGNC:107237
Rattus norvegicus CPEB2 RGD RGD:1307485
Mus musculus CPEB2 MGD MGI:2442640
Felis catus CPEB2 VGNC VGNC:78474
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