2. Gene
  3. Drd3 - dopamine receptor D3 Gene

Drd3 - dopamine receptor D3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：多巴胺受体 D3

种属: Mus musculus

同用名: D3R

基因 ID: 13490 | 基因类型: protein coding

关于 Drd3

Chromosome 16: 43,574,389-43,643,295 forward strand.GRCm39:CM001009.3

This gene has 2 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 39 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白可启动多巴胺神经递质受体活性，通过 Gi/Go 耦合。参与对可卡因的行为反应和神经递质摄取的调节。作用于多个过程的上游或内部，包括调节血压；调节多巴胺受体信号通路；和对生物碱的反应。位于质膜。在多巴胺能突触中活跃。以多种结构表达，包括大脑；外分泌腺；泌尿生殖系统；直觉;和感觉器官。用于研究不宁腿综合症。该基因的人类直系同源物与帕金森病有关；特发性震颤;原发性震颤 1；和精神分裂症。与人类 DRD3（多巴胺受体 D3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including regulation of blood pressure; regulation of Dopamine Receptor signaling pathway; and response to alkaloid. Located in plasma membrane. Is active in dopaminergic synapse. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (Dopamine Receptor D3). [provided by Alliance of Genome Resources, Apr 2022]

Drd3 基因产物(1)

mRNA Protein Name
NM_007877.2 NP_031903.1 D(3) dopamine receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
IDA: 通过直接分析推断
7566118 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16386234 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of G protein-coupled dopamine receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
12097513 MGI
acts upstream of G protein-coupled dopamine receptor signaling pathway IMP
IMP: 通过突变表型推断
15016423 MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway IDA
IDA: 通过直接分析推断
16386234 MGI
involved in behavioral response to cocaine IMP
IMP: 通过突变表型推断
10432116 MGI
acts upstream of or within circadian regulation of gene expression IMP
IMP: 通过突变表型推断
15878801 MGI
acts upstream of or within locomotory behavior IGI
IGI: 通过遗传相互作用推断
9354330 MGI
NOT acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
10221759 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
8700864 MGI
acts upstream of or within musculoskeletal movement, spinal reflex action IMP
IMP: 通过突变表型推断
15601940 MGI
acts upstream of or within negative regulation of blood pressure IMP
IMP: 通过突变表型推断
9691085 MGI
acts upstream of or within negative regulation of dopamine receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
12097513 MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation IDA
IDA: 通过直接分析推断
9651217 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
17251429 MGI
acts upstream of oligodendrocyte differentiation IDA
IDA: 通过直接分析推断
9651217 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
17251429 MGI
acts upstream of or within positive regulation of dopamine receptor signaling pathway IMP
IMP: 通过突变表型推断
15016423 MGI
acts upstream of or within regulation of blood volume by renin-angiotensin IGI
IGI: 通过遗传相互作用推断
9691085 MGI
acts upstream of or within regulation of blood volume by renin-angiotensin IMP
IMP: 通过突变表型推断
9691085 MGI
acts upstream of or within regulation of dopamine secretion IMP
IMP: 通过突变表型推断
9482807 MGI
acts upstream of or within regulation of lipid metabolic process IMP
IMP: 通过突变表型推断
15084447 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
15084447 MGI
involved in regulation of neurotransmitter uptake EXP
EXP: 通过实验结果推断
27393374 MGI
involved in regulation of neurotransmitter uptake IDA
IDA: 通过直接分析推断
27393374 MGI
acts upstream of or within response to amphetamine IGI
IGI: 通过遗传相互作用推断
12097513 MGI
acts upstream of or within response to cocaine IMP
IMP: 通过突变表型推断
10943692 MGI
NOT acts upstream of or within response to ethanol IMP
IMP: 通过突变表型推断
12873629 MGI
acts upstream of or within response to ethanol IMP
IMP: 通过突变表型推断
11988344 MGI
acts upstream of or within response to morphine IMP
IMP: 通过突变表型推断
12574430 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
12097513 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in dopaminergic synapse EXP
EXP: 通过实验结果推断
27393374 MGI
is active in dopaminergic synapse IDA
IDA: 通过直接分析推断
27393374 MGI
located in membrane IDA
IDA: 通过直接分析推断
9651217 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
9651217 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Drd3 蛋白结构

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (29 - 439)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (30 - 56)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (63 - 86)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (102 - 132)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (149 - 167)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (184 - 209)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (367 - 397)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (407 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
蛋白主名 其他名称

D(3) dopamine receptor

dopamine D3 receptor

dopamine receptor 3

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-19654 GSK598809 Antagonist 99.74% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19654C (-)-GSK598809 hydrochloride Antagonist 99.64% 否
HY-RS04000 DRD3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04001 Drd3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04002 Drd3 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-19654B (-)-GSK598809 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Drd3 NCBI NCBI:1814
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