STXBP5 - syntaxin binding protein 5 Gene

中文名称：突触融合蛋白结合蛋白 5

种属: Homo sapiens

同用名: LGL3; LLGL3; Nbla04300

关于 STXBP5

功能概要

Syntaxin 1 是 7S 和 20S SNARE 复合物的组成部分，它们参与突触小泡与突触前质膜的对接和融合。该基因编码突触融合蛋白 1 结合蛋白。在大鼠体内，一种类似的蛋白质将突触融合蛋白 1 从 Munc18/n-Sec1/rbSec1 复合体中解离出来，形成 10S 复合体，这是一种可以转化为 7S SNARE 复合体的中间体。因此，这种蛋白质被认为通过刺激 SNARE 复合物的形成而参与神经递质释放。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]