1. Gene
  2. TRIM40 - tripartite motif containing 40 Gene

TRIM40 - tripartite motif containing 40 Gene

中文名称:含三方主题 40

种属: Homo sapiens

同用名: RNF35

基因 ID: 135644 | 基因类型: protein coding

关于 TRIM40

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,136,140-30,148,735 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 76 orthologues and 80 paralogues. Biased expression in small intestine (RPKM 3.6), duodenum (RPKM 3.4) and 4 other tissues.

功能概要

该基因编码三联基序 (tripartite motif, TRIM) 蛋白家族的成员。编码的蛋白质可能作为胃肠道炎症和癌变的负调节剂发挥作用。已经描述了编码不同蛋白质同种型的可变剪接转录物变体。[RefSeq 提供,2014 年 2 月]

This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Feb 2014]

TRIM40 基因产物(2)

mRNA Protein Name
NM_001286633.2 NP_001273562.1 E3 ubiquitin ligase TRIM40 isoform a
NM_138700.4 NP_619645.1 E3 ubiquitin ligase TRIM40 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21474709 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
21474709 GOA
involved in negative regulation of protein catabolic process IDA
IDA: 通过直接分析推断
21474709 GOA
involved in negative regulation of protein localization to nucleus IDA
IDA: 通过直接分析推断
21474709 GOA
involved in protein neddylation IDA
IDA: 通过直接分析推断
21474709 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of IkappaB kinase complex IDA
IDA: 通过直接分析推断
21474709 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIM40 蛋白结构

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (14 - 56)

  • 0
  • 100
  • 200
  • 258 a.a.
蛋白主名 其他名称

E3 ubiquitin ligase TRIM40

RING finger protein 35

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TRIM40 RGD RGD:1359645
Bos taurus TRIM40 VGNC VGNC:54243
Mus musculus TRIM40 MGD MGI:2684881