2. Gene
  3. Edn1 - endothelin 1 Gene

Edn1 - endothelin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ET-1; PPET1; preproET

基因 ID: 13614 | 基因类型: protein coding

关于 Edn1

功能概要

This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of central nervous activity. Mice lacking the encoded protein exhibit neonatal lethality accompanied with numerous craniofacial and cardiovascular defects due to disruption in cranial and cardiac neural crest cell patterning during early embryogenesis. [provided by RefSeq, Feb 2016]

Edn1 基因产物(1)

mRNA Protein Name
NM_010104.4 NP_034234.1 endothelin-1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endothelin A receptor binding IPI
IPI: 通过物理相互作用推断
9449664 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12441350 MGI
enables receptor ligand activity IDA
IDA: 通过直接分析推断
24722437 MGI
enables signaling receptor binding IDA
IDA: 通过直接分析推断
2542249 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
20929948 MGI
involved in MAPK cascade IDA
IDA: 通过直接分析推断
19111534 MGI
involved in MAPK cascade IMP
IMP: 通过突变表型推断
19111534 MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
2542249 MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
15632412 MGI
involved in axon extension IDA
IDA: 通过直接分析推断
18401410 MGI
involved in axon guidance IMP
IMP: 通过突变表型推断
30735130 MGI
involved in axonogenesis involved in innervation IMP
IMP: 通过突变表型推断
24875861 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: 通过突变表型推断
7615798 MGI
acts upstream of or within body fluid secretion IMP
IMP: 通过突变表型推断
15314687 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
7615798 MGI
involved in branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
23933587 MGI
involved in calcium ion transmembrane transport IDA
IDA: 通过直接分析推断
24722437 MGI
involved in canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
24722437 MGI
involved in cardiac neural crest cell migration involved in outflow tract morphogenesis IDA
IDA: 通过直接分析推断
31219639 MGI
acts upstream of or within cartilage development IMP
IMP: 通过突变表型推断
8152482 MGI
involved in cellular response to follicle-stimulating hormone stimulus IDA
IDA: 通过直接分析推断
19111534 MGI
involved in cellular response to human chorionic gonadotropin stimulus IDA
IDA: 通过直接分析推断
19111534 MGI
involved in cellular response to luteinizing hormone stimulus IDA
IDA: 通过直接分析推断
19111534 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: 通过突变表型推断
15110048 MGI
involved in embryonic heart tube development IMP
IMP: 通过突变表型推断
24875861 MGI
involved in endothelin receptor signaling pathway IDA
IDA: 通过直接分析推断
24722437 MGI
involved in endothelin receptor signaling pathway involved in heart process IDA
IDA: 通过直接分析推断
31219639 MGI
involved in gene expression IDA
IDA: 通过直接分析推断
20929948 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
20516397 MGI
involved in glomerular endothelium development IDA
IDA: 通过直接分析推断
31402170 MGI
involved in glomerular filtration IDA
IDA: 通过直接分析推断
31402170 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
7615798 MGI
involved in heart development IMP
IMP: 通过突变表型推断
24875861 MGI
involved in heart process IMP
IMP: 通过突变表型推断
25197047 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
15327783 MGI
involved in meiotic cell cycle process involved in oocyte maturation IDA
IDA: 通过直接分析推断
19111534 MGI
acts upstream of or within middle ear morphogenesis IMP
IMP: 通过突变表型推断
8152482 MGI
involved in mitochondrion organization IDA
IDA: 通过直接分析推断
27899487 MGI
acts upstream of or within neural crest cell development IMP
IMP: 通过突变表型推断
9671575 MGI
involved in neural crest cell differentiation IMP
IMP: 通过突变表型推断
23933587 MGI
involved in neural crest cell fate commitment IMP
IMP: 通过突变表型推断
23933587 MGI
involved in neuron projection development IDA
IDA: 通过直接分析推断
24875861 MGI
involved in noradrenergic neuron differentiation IMP
IMP: 通过突变表型推断
24875861 MGI
involved in pharyngeal arch artery morphogenesis IMP
IMP: 通过突变表型推断
23933587 MGI
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
2542249 MGI
acts upstream of or within phospholipase D-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
8978712 MGI
involved in podocyte differentiation IDA
IDA: 通过直接分析推断
31402170 MGI
involved in positive regulation of artery morphogenesis IMP
IMP: 通过突变表型推断
20495147 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
24722437 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
2542249 MGI
involved in positive regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
21525433 MGI
acts upstream of or within positive regulation of renal sodium excretion IMP
IMP: 通过突变表型推断
15314687 MGI
acts upstream of or within positive regulation of smooth muscle contraction IDA
IDA: 通过直接分析推断
8010105 MGI
acts upstream of or within positive regulation of urine volume IGI
IGI: 通过遗传相互作用推断
15632412 MGI
acts upstream of or within positive regulation of urine volume IMP
IMP: 通过突变表型推断
15632412 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
31219639 MGI
acts upstream of or within regulation of D-glucose transmembrane transport IDA
IDA: 通过直接分析推断
11546805 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: 通过突变表型推断
8152482 MGI
involved in regulation of blood pressure IMP
IMP: 通过突变表型推断
16868309 MGI
acts upstream of or within regulation of pH IDA
IDA: 通过直接分析推断
11413164 MGI
involved in renal sodium ion absorption IDA
IDA: 通过直接分析推断
23698114 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: 通过突变表型推断
10626068 MGI
involved in response to amphetamine IMP
IMP: 通过突变表型推断
24875861 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
8764295 MGI
acts upstream of or within rhythmic excitation IMP
IMP: 通过突变表型推断
8764295 MGI
involved in semaphorin-plexin signaling pathway involved in axon guidance IMP
IMP: 通过突变表型推断
30735130 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
8152482 MGI
acts upstream of smooth muscle contraction IDA
IDA: 通过直接分析推断
8010105 MGI
involved in sympathetic neuron axon guidance IMP
IMP: 通过突变表型推断
30735130 MGI
involved in thyroid gland development IMP
IMP: 通过突变表型推断
26506449 MGI
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
27026367 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
24722437 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
15314687 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

endothelin-1

preproendothelin-1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04162 EDN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04163 Edn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17406 Edn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Edn1 NCBI NCBI:1906
Rattus norvegicus Edn1 NCBI NCBI:24323
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z