MTPN - myotrophin Gene

中文名称：肌营养蛋白

种属: Homo sapiens

同用名: V-1; GCDP

关于 MTPN

功能概要

该基因产生的转录物是双顺反子，可以编码肌营养蛋白和亮氨酸拉链蛋白 6。肌营养蛋白与心脏肥大相关，参与 NFkappa B p50-p65 异二聚体向 p50-p50 和 p65 的转化-p65 同型二聚体。这种蛋白质在小脑形态发生中也具有潜在功能，它可能参与小脑神经元的分化，尤其是颗粒细胞的分化。该转录物 3' 端的隐蔽 ORF 使用新的内部核糖体进入位点和非 AUG 翻译起始密码子来产生亮氨酸拉链蛋白 6，这是一种与骨髓增生性疾病相关的 6.4 kDa 肿瘤抗原。[RefSeq 提供，2008 年 7 月]

The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]