2. Gene
  3. Ercc2 - excision repair cross-complementing rodent repair deficiency, complementation group 2 Gene

Ercc2 - excision repair cross-complementing rodent repair deficiency, complementation group 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: XPD; CXPD; Ercc-2; RCO015; Mhdarco15

基因 ID: 13871 | 基因类型: protein coding

关于 Ercc2

功能概要

Predicted to enable several functions, including 5'-3' DNA helicase activity; protein C-terminus binding activity; and protein N-terminus binding activity. Acts upstream of or within several processes, including animal organ development; neurogenesis; and nucleic acid metabolic process. Located in nucleus. Is expressed in central nervous system; eye; hair follicle; and liver. Used to study photosensitive trichothiodystrophy and xeroderma pigmentosum group D. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic Cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc2 基因产物(2)

mRNA Protein Name
NM_001363981.1 NP_001350910.1 general transcription and DNA repair factor IIH helicase subunit XPD isoform 2
NM_007949.5 NP_031975.2 general transcription and DNA repair factor IIH helicase subunit XPD isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA repair IMP
IMP: 通过突变表型推断
11950998 MGI
acts upstream of or within UV protection IMP
IMP: 通过突变表型推断
9651581 MGI
acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
17020410 MGI
acts upstream of or within central nervous system myelin formation IMP
IMP: 通过突变表型推断
17952069 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: 通过突变表型推断
11950998 MGI
acts upstream of or within embryonic cleavage IMP
IMP: 通过突变表型推断
9426063 MGI
acts upstream of or within erythrocyte maturation IMP
IMP: 通过突变表型推断
17020410 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: 通过突变表型推断
9651581 MGI
acts upstream of or within hair cell differentiation IMP
IMP: 通过突变表型推断
17020410 MGI
acts upstream of or within hair cycle process IMP
IMP: 通过突变表型推断
17020410 MGI
acts upstream of or within hair follicle maturation IMP
IMP: 通过突变表型推断
9651581 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: 通过突变表型推断
17554309 MGI
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: 通过突变表型推断
17554309 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
17020410 MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
18545656 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
18545656 MGI
acts upstream of or within maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
IMP: 通过突变表型推断
23562818 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
17020410 MGI
acts upstream of or within nucleotide-excision repair IMP
IMP: 通过突变表型推断
9651581 MGI
acts upstream of or within positive regulation of DNA binding IMP
IMP: 通过突变表型推断
17952069 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
11950998 MGI
acts upstream of or within response to UV IMP
IMP: 通过突变表型推断
17020410 MGI
acts upstream of or within response to oxidative stress IMP
IMP: 通过突变表型推断
11950998 MGI
acts upstream of or within ribosomal small subunit biogenesis IMP
IMP: 通过突变表型推断
23562818 MGI
acts upstream of or within skin development IMP
IMP: 通过突变表型推断
9651581 MGI
acts upstream of or within spinal cord development IMP
IMP: 通过突变表型推断
17020410 MGI
acts upstream of or within transcription elongation by RNA polymerase I IMP
IMP: 通过突变表型推断
23562818 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
17952069 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

general transcription and DNA repair factor IIH helicase subunit XPD

DNA excision repair protein ERCC-2

DNA repair protein complementing XP-D cells

TFIIH basal transcription factor complex helicase XPD subunit

xeroderma pigmentosum group D-complementing protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04479 ERCC2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22491 Ercc2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29014 Ercc2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ercc2 NCBI NCBI:2068
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