Esr1 - estrogen receptor 1 (alpha) Gene

中文名称：雌激素受体 1 (α)

种属: Mus musculus

同用名: ER; ERa; ESR; Estr; Estra; Nr3a1; ERalpha; ER-alpha

关于 Esr1

功能概要

该基因编码一种雌激素受体，它是细胞内受体核激素家族的一员。由性激素雌激素激活的编码蛋白是一种转录因子，由几个对激素结合、DNA 结合和转录激活很重要的结构域组成。雌激素及其受体对性发育和生殖功能至关重要，但也在骨骼等其他组织中发挥作用。人类的相似基因与包括乳腺癌、子宫内膜癌和骨质疏松症在内的病理过程有关。可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 10 月]

This gene encodes an Estrogen Receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast Cancer, endometrial Cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]