2. Gene
  3. Fbn2 - fibrillin 2 Gene

Fbn2 - fibrillin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: sy; sne; Fib-2; mKIAA4226

基因 ID: 14119 | 基因类型: protein coding

关于 Fbn2

功能概要

Predicted to be an extracellular matrix structural constituent. Involved in several processes, including bone trabecula formation; positive regulation of osteoblast differentiation; and sequestering of TGFbeta in extracellular matrix. Acts upstream of or within embryonic limb morphogenesis. Located in extracellular region and microfibril. Is expressed in several structures, including connective tissue; embryo mesenchyme; genitourinary system; heart; and respiratory system. Used to study distal arthrogryposis. Human ortholog(s) of this gene implicated in congenital contractural arachnodactyly and scoliosis. Orthologous to human FBN2 (fibrillin 2). [provided by Alliance of Genome Resources, Apr 2022]

Fbn2 基因产物(1)

mRNA Protein Name
NM_010181.2 NP_034311.2 fibrillin-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone activity IDA
IDA: 通过直接分析推断
32329225 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
25762570 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bone trabecula formation IMP
IMP: 通过突变表型推断
20855508 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: 通过突变表型推断
11285249 MGI
involved in glucose homeostasis IDA
IDA: 通过直接分析推断
32329225 MGI
acts upstream of or within limb morphogenesis IMP
IMP: 通过突变表型推断
10700192 MGI
involved in positive regulation of bone mineralization IMP
IMP: 通过突变表型推断
20855508 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
20855508 MGI
involved in sequestering of TGFbeta in extracellular matrix IMP
IMP: 通过突变表型推断
20855508 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
24348270 MGI
located in microfibril IDA
IDA: 通过直接分析推断
24348270 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

fibrillin-2

syndatyly ems

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04777 FBN2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22168 Fbn2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28690 Fbn2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fbn2 NCBI NCBI:2201
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