CRYGS - crystallin gamma S Gene

中文名称：结晶γS

种属: Homo sapiens

同用名: CRYG8; CTRCT20

基因 ID: 1427 | 基因类型: protein coding

关于 CRYGS

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,538,443-186,544,380 (from NCBI)

This gene has 3 transcripts (splice variants), 218 orthologues, 14 paralogues and is associated with 4 phenotypes. Ubiquitous expression in spleen (RPKM 1.8), skin (RPKM 1.8) and 25 other tissues.

功能概要

晶状体蛋白分为两类：分类群特异性或酶类，以及普遍存在的。后一类构成脊椎动物眼睛晶状体的主要蛋白质，并维持晶状体的透明度和折射率。由于晶状体中央纤维细胞在发育过程中会失去细胞核，因此会产生这些晶状体蛋白并在整个生命过程中保留下来，从而使它们成为极其稳定的蛋白质。哺乳动物晶状体蛋白分为 alpha、beta 和 gamma 家族； beta 和 γ 晶状体蛋白也被认为是一个超家族。 Alpha 和 Beta 家族进一步分为酸性和碱性组。晶状体蛋白中存在七个蛋白质区域：四个同源基序、一个连接肽以及 N 和 C 末端延伸。 γ-晶状体蛋白是一组同质的高度对称的单体蛋白质，通常缺乏连接肽和末端延伸。它们在早期发育后受到不同的调节。该基因编码的蛋白质最初被认为是β-晶状体蛋白，但编码的蛋白质是单体的，与其他γ-晶状体蛋白具有更大的序列相似性。该基因编码成人眼睛晶状体组织中最重要的γ-晶状体蛋白。无论是由于衰老还是特定基因的突变，γ-晶状体蛋白都参与了白内障的形成。[RefSeq 提供，2008 年 7 月]

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to Other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]

CRYGS 基因产物(1)

mRNA	Protein	Name
NM_017541.4	NP_060011.1	gamma-crystallin S

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24183572	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRYGS 蛋白结构

Crystall

0
100
178 a.a.

蛋白主名

其他名称

gamma-crystallin S

beta-crystallin S

关联疾病

疾病名称

别名

Cataract 20, Multiple Types

CTRCT20

Cataract 20 Multiple Types

Early-Onset Sutural Cataract

Early-Onset Cataract With Y-Shaped Suture Opacities

Early-Onset Lamellar Cataract

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Nuclear Senile Cataract

Senile Nuclear Cataract

Senile Nuclear Sclerosis

Mature Cataract

Total Or Mature Cataract

Total, Mature Senile Cataract

Morgagni Cataract

Hypermature Cataract

Morgagnian Cataract

Eye Accommodation Disease

Deprivation Amblyopia

Disuse Amblyopia

Stimulus Deprivation Amblyopia

Presbyopia

Subnormal Accommodation

Accommodation Insufficiency Of Old Age

Immature Cataract

Incipient Cataract	Incipient Senile Cataract
Water Clefts

Senile Cataract

Lens Disease

Lens Diseases

Axenfeld-Rieger Syndrome, Type 3

Axenfeld-Rieger Syndrome Type 3	RIEG3
Anterior Chamber Cleavage Syndrome	Anterior Segment Mesenchymal Dysgenesis
Axenfeld-Rieger Anomaly With Cardiac Defects And/Or Sensorineural Hearing Loss	Axenfeld-Rieger Anomaly With Or Without Cardiac Defects And/Or Sensorineural Hearing Loss
Rieger Syndrome Type 3	Axenfeld-Rieger Anomaly
Rieger Syndrome, Type 3	Axenfeld-Rieger Syndrome 3
Axenfeld Anomaly	Rieger Anomaly
Rieger Syndrome	Rieger Eye Malformation Sequence

Diabetic Cataract

Cataract - Diabetic

Galactosemia Ii

Galactokinase Deficiency	Galk Deficiency
Galactokinase Deficiency With Cataracts	Deficiency Of Galactokinase
GALAC2	Galk-D
Galactokinase Deficiency Galactosemia	Galactosemia 2
Galactosemia Type 2	Hereditary Galactokinase Deficiency
Galactokinase Deficiency, Cataract	Galactosemias
Galk - [Galactokinase Deficiency]

Posterior Polar Cataract

Cataract, Posterior Polar

Amblyopia

Lazy Eye

Retinal Perforation

Retinal Break	Retinal Perforations
Retinal Dialysis	Retinal Tear
Retinal Break Nos	Ruptured Retina

Nance-Horan Syndrome

NHS	Cataract-Dental Syndrome
Cataract, X-Linked, With Hutchinsonian Teeth	Mesiodens-Cataract Syndrome
Cataract X-Linked With Hutchinsonian Teeth	Cataract Dental Syndrome
Mesiodens Cataract Syndrome

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment	Ncrna Disease
Non-Syndromic Congenital Retinal Non-Attachment	Pfvs
Phpv	Persistent Fetal Vasculature Syndrome

Coloboma Of Optic Nerve

Morning Glory Disc Anomaly	Coloboma Of Optic Disc
Morning Glory Syndrome	Ectasic Coloboma
Coloboma Of Optic Papilla	Congenital Coloboma Of The Optic Nerve
Optic Nerve Coloboma	Optic Nerve Head Pits, Bilateral Congenital
Volubilis Syndrome	COLON
Coloboma Of Optic Disc, Unspecified Eye	Congenital Coloboma Of Optic Disc
Optic Disk Coloboma

Axenfeld-Rieger Syndrome

Axenfeld Syndrome	Rieger Syndrome
Rieger Anomaly	Axenfeld Anomaly
Anomaly, Rieger'S	Hagedoom Syndrome
Rgs - Rieger Syndrome	Rieger'S Anomaly
Goniodysgenesis Hypodontia	Iridogoniodysgenesis With Somatic Anomalies
Ars	Axenfeld And Rieger Anomaly
Axra	Axrs
Rieger Eye Malformation Sequence

Aniridia 1

Aniridia	Congenital Aniridia
AN1	An
Cataract With Late-Onset Corneal Dystrophy	Aplasia Of Iris
Absent Iris	Irideremia
Aniridia Ii, Formerly	An2, Formerly
An2	Aniridia Type Ii
Aniridia, Type 1	An-1
Absence Of Iris	Agenesis Of Iris
Congenital Absence Of Iris	Hereditary Aniridia
Sporadic Aniridia

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03216	CRYGS Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CRYGS	VGNC	VGNC:39646
Rattus norvegicus	CRYGS	RGD	RGD:1587483
Macaca mulatta	CRYGS	VGNC	VGNC:84196
Mus musculus	CRYGS	MGD	MGI:1298216
Bos taurus	CRYGS	VGNC	VGNC:27743
Felis catus	CRYGS	VGNC	VGNC:61207

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CRYGS - crystallin gamma S Gene

关于 CRYGS

功能概要

CRYGS 基因产物(1)

CRYGS 蛋白结构

关联疾病

直系同源

热门区域

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CRYGS - crystallin gamma S Gene

关于 CRYGS

功能概要

CRYGS 基因产物(1)

CRYGS 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z