2. Gene
  3. PIWIL4 - piwi like RNA-mediated gene silencing 4 Gene

PIWIL4 - piwi like RNA-mediated gene silencing 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：piwi 样 RNA 介导的基因沉默 4

种属: Homo sapiens

同用名: HIWI2; MIWI2

基因 ID: 143689 | 基因类型: protein coding

关于 PIWIL4

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,567,368-94,621,421 (from NCBI)

This gene has 5 transcripts (splice variants), 117 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 9.2), testis (RPKM 8.7) and 19 other tissues.

功能概要

PIWIL4 属于 Argonaute 蛋白家族，在生殖系干细胞的发育和维持中起作用 (Sasaki 等人，2003 [PubMed 12906857]) 。[OMIM 提供，2008 年 3 月]

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]

PIWIL4 基因产物(1)

mRNA Protein Name
NM_152431.3 NP_689644.2 piwi-like protein 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables piRNA binding IDA
IDA: 通过直接分析推断
25038252 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epithelial structure maintenance IMP
IMP: 通过突变表型推断
28025795 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
28025795 GOA
located in nucleus IDA
IDA: 通过直接分析推断
28025795 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIWIL4 蛋白结构

PAZ

PAZ: PAZ domain (272 - 406)

Piwi

Piwi: Piwi domain (547 - 838)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 852 a.a.
蛋白主名 其他名称

piwi-like protein 4

piwi-like 4

PIWIL4 抗体

目录号 产品名 应用 反应物种
HY-P84654 PIWIL4 Antibody (YA4351) WB, IHC-P, FC, ELISA Human

关联疾病

疾病名称 别名
Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type

CHH

Mckusick Type Metaphyseal Chondrodysplasia

Metaphyseal Dysplasia Without Hypotrichosis

Cartilage Hair Hypoplasia Like Syndrome

Metaphyseal Chondrodysplasia Mckusick Type

Chhv

Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

Cartilage-Hair Syndrome

Mckusick'S Metaphyseal Chondrodysplasia Syndrome

Metaphyseal Chondrodysplasia, Recessive Type

Autosomal Recessive Metaphyseal Chondrodysplasia
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10587 PIWIL4 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PIWIL4 VGNC VGNC:81959
Macaca mulatta PIWIL4 VGNC VGNC:81504
Rattus norvegicus PIWIL4 RGD RGD:1311015
Mus musculus PIWIL4 MGD MGI:3041167
Canis familiaris PIWIL4 VGNC VGNC:44594
Bos taurus PIWIL4 VGNC VGNC:32930
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