2. Gene
  3. Gli2 - GLI-Kruppel family member GLI2 Gene

Gli2 - GLI-Kruppel family member GLI2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 14633 | 基因类型: protein coding

关于 Gli2

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of smoothened signaling pathway. Located in several cellular components, including axoneme; ciliary tip; and nuclear speck. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Orthologous to human GLI2 (Gli family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Gli2 基因产物(1)

mRNA Protein Name
NM_001081125.1 NP_001074594.1 zinc finger protein GLI2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16880529 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
16880529 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15614767 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
23201751 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
16396903 MGI
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
25808752 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11238441 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16611981 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
19124651 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within anatomical structure development IGI
IGI: 通过遗传相互作用推断
11485934 MGI
acts upstream of or within anatomical structure development IMP
IMP: 通过突变表型推断
11485934 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: 通过遗传相互作用推断
9731531 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
22841643 MGI
acts upstream of or within axon guidance IMP
IMP: 通过突变表型推断
10409510 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: 通过突变表型推断
9731531 MGI
acts upstream of or within cell differentiation IMP
IMP: 通过突变表型推断
9636069 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
15496441 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
9731531 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
19103752 MGI
acts upstream of or within cerebellar cortex morphogenesis IGI
IGI: 通过遗传相互作用推断
16571625 MGI
acts upstream of or within cerebellar cortex morphogenesis IMP
IMP: 通过突变表型推断
16571625 MGI
acts upstream of or within chondrocyte differentiation IGI
IGI: 通过遗传相互作用推断
23333501 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: 通过突变表型推断
17395647 MGI
acts upstream of or within developmental growth IMP
IMP: 通过突变表型推断
16571630 MGI
acts upstream of or within dorsal/ventral neural tube patterning IDA
IDA: 通过直接分析推断
9247260 MGI
acts upstream of or within dorsal/ventral neural tube patterning IMP
IMP: 通过突变表型推断
18590716 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: 通过遗传相互作用推断
16342201 MGI
acts upstream of or within embryonic digestive tract development IMP
IMP: 通过突变表型推断
10693670 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: 通过突变表型推断
19056373 MGI
acts upstream of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
16054035 MGI
acts upstream of epithelial cell proliferation IMP
IMP: 通过突变表型推断
9731531 MGI
acts upstream of or within floor plate formation IMP
IMP: 通过突变表型推断
9636069 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
23201751 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
29659575 MGI
acts upstream of or within head development IMP
IMP: 通过突变表型推断
19056373 MGI
acts upstream of or within heart development IGI
IGI: 通过遗传相互作用推断
11172440 MGI
acts upstream of or within hindbrain development IGI
IGI: 通过遗传相互作用推断
15496441 MGI
acts upstream of or within hindbrain development IMP
IMP: 通过突变表型推断
8575294 MGI
acts upstream of or within hindgut morphogenesis IGI
IGI: 通过遗传相互作用推断
11485934 MGI
acts upstream of or within hindgut morphogenesis IMP
IMP: 通过突变表型推断
11485934 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
19056373 MGI
acts upstream of or within kidney development IGI
IGI: 通过遗传相互作用推断
11172440 MGI
acts upstream of or within lung development IGI
IGI: 通过遗传相互作用推断
10725236 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
9731531 MGI
acts upstream of or within mammary gland development IMP
IMP: 通过突变表型推断
11783999 MGI
acts upstream of or within mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
11783999 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: 通过突变表型推断
16707121 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
19056373 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: 通过突变表型推断
17328886 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
28778798 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16611981 MGI
acts upstream of or within neural tube development IMP
IMP: 通过突变表型推断
19056373 MGI
acts upstream of or within neuron development IMP
IMP: 通过突变表型推断
16267219 MGI
acts upstream of neuron differentiation IGI
IGI: 通过遗传相互作用推断
16950124 MGI
acts upstream of or within notochord regression IGI
IGI: 通过遗传相互作用推断
10725236 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
9655803 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: 通过突变表型推断
9655803 MGI
acts upstream of or within osteoblast development IDA
IDA: 通过直接分析推断
16880529 MGI
acts upstream of or within osteoblast development IMP
IMP: 通过突变表型推断
16880529 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: 通过遗传相互作用推断
22771375 MGI
acts upstream of or within pattern specification process IGI
IGI: 通过遗传相互作用推断
14602680 MGI
acts upstream of or within pattern specification process IMP
IMP: 通过突变表型推断
8575294 MGI
acts upstream of or within pituitary gland development IGI
IGI: 通过遗传相互作用推断
10725236 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15614767 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16254602 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18590716 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
17035233 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
15496441 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15496441 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
16054035 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
9731531 MGI
acts upstream of or within positive regulation of neuron differentiation IGI
IGI: 通过遗传相互作用推断
16950124 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
9731531 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16880529 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16880529 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16880529 MGI
acts upstream of or within prostatic bud formation IMP
IMP: 通过突变表型推断
16707121 MGI
acts upstream of or within proximal/distal pattern formation IGI
IGI: 通过遗传相互作用推断
16342201 MGI
acts upstream of or within regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
28817564 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
9006072 MGI
acts upstream of or within smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
16571625 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: 通过突变表型推断
16571625 MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning IGI
IGI: 通过遗传相互作用推断
17395647 MGI
acts upstream of or within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IGI
IGI: 通过遗传相互作用推断
15215207 MGI
acts upstream of or within smoothened signaling pathway involved in ventral spinal cord interneuron specification IGI
IGI: 通过遗传相互作用推断
15215207 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IGI
IGI: 通过遗传相互作用推断
15215207 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IMP
IMP: 通过突变表型推断
11748151 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: 通过突变表型推断
21552265 MGI
acts upstream of or within spinal cord ventral commissure morphogenesis IMP
IMP: 通过突变表型推断
10409510 MGI
acts upstream of stem cell proliferation IMP
IMP: 通过突变表型推断
9731531 MGI
acts upstream of or within tube development IGI
IGI: 通过遗传相互作用推断
9731531 MGI
acts upstream of or within ventral midline development IGI
IGI: 通过遗传相互作用推断
10725236 MGI
acts upstream of or within ventral midline development IMP
IMP: 通过突变表型推断
10725236 MGI
acts upstream of or within ventral spinal cord development IMP
IMP: 通过突变表型推断
11748151 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axoneme IDA
IDA: 通过直接分析推断
21209331 MGI
located in ciliary tip IDA
IDA: 通过直接分析推断
21653639 MGI
located in cilium IDA
IDA: 通过直接分析推断
16254602 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
19286674 MGI
located in cytoplasm IGI
IGI: 通过遗传相互作用推断
16316410 MGI
located in membrane IDA
IDA: 通过直接分析推断
19286674 MGI
located in motile cilium IDA
IDA: 通过直接分析推断
18590716 MGI
located in nuclear speck IDA
IDA: 通过直接分析推断
19684112 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11238441 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

zinc finger protein GLI2

Tax helper protein

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13901 GANT 61 99.66% 否
HY-RS05475 GLI2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-12487 NL-103 Inhibitor / 否
HY-137567 Prostaglandin E1 ethanolamide Activator / 否
HY-RS05481 GLIS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20743 Gli2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21582 Glis2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27255 Gli2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28100 Glis2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gli2 NCBI NCBI:2736
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z