2. Gene
  3. Gli3 - GLI-Kruppel family member GLI3 Gene

Gli3 - GLI-Kruppel family member GLI3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Xt; Bph; Pdn; add; GLI3FL; GLI3-190

基因 ID: 14634 | 基因类型: protein coding

关于 Gli3

功能概要

Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative thymic T cell selection; regulation of alpha-beta T cell differentiation; and thymocyte apoptotic process. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of cell differentiation. Located in axoneme and nuclear speck. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Greig cephalopolysyndactyly syndrome and Pallister-Hall syndrome. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (Gli family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Gli3 基因产物(1)

mRNA Protein Name
NM_008130.3 NP_032156.2 transcriptional activator GLI3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
11053430 MGI
enables chromatin binding IGI
IGI: 通过遗传相互作用推断
16396903 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10920228 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16611981 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell differentiation in thymus IMP
IMP: 通过突变表型推断
15855276 MGI
involved in T cell differentiation in thymus IMP
IMP: 通过突变表型推断
15855276 MGI
acts upstream of or within alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
15855276 MGI
acts upstream of or within anatomical structure development IGI
IGI: 通过遗传相互作用推断
11485934 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: 通过遗传相互作用推断
9731531 MGI
acts upstream of or within anterior semicircular canal development IMP
IMP: 通过突变表型推断
17395647 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
22841643 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
15315762 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
19048639 MGI
acts upstream of or within artery development IGI
IGI: 通过遗传相互作用推断
16968815 MGI
acts upstream of or within axon guidance IMP
IMP: 通过突变表型推断
15065125 MGI
acts upstream of or within brain development IMP
IMP: 通过突变表型推断
8026071 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: 通过遗传相互作用推断
16396903 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: 通过突变表型推断
16247775 MGI
acts upstream of or within camera-type eye development IGI
IGI: 通过遗传相互作用推断
18582859 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: 通过突变表型推断
8387379 MGI
acts upstream of or within cell differentiation involved in kidney development IGI
IGI: 通过遗传相互作用推断
19809516 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
16396903 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
16396903 MGI
acts upstream of or within central nervous system development IGI
IGI: 通过遗传相互作用推断
12435628 MGI
acts upstream of or within central nervous system development IMP
IMP: 通过突变表型推断
12435629 MGI
acts upstream of or within cerebral cortex radial glia-guided migration IMP
IMP: 通过突变表型推断
9232833 MGI
acts upstream of chondrocyte differentiation IGI
IGI: 通过遗传相互作用推断
16284117 MGI
acts upstream of or within developmental growth IMP
IMP: 通过突变表型推断
9268579 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: 通过突变表型推断
12435629 MGI
acts upstream of or within embryonic digestive tract development IMP
IMP: 通过突变表型推断
10693670 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: 通过突变表型推断
16247775 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: 通过遗传相互作用推断
9268572 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: 通过突变表型推断
9268572 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: 通过遗传相互作用推断
16284117 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: 通过突变表型推断
8387379 MGI
acts upstream of or within embryonic morphogenesis IMP
IMP: 通过突变表型推断
8387379 MGI
acts upstream of or within embryonic neurocranium morphogenesis IMP
IMP: 通过突变表型推断
27395007 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: 通过遗传相互作用推断
15728667 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
16168404 MGI
acts upstream of or within forebrain dorsal/ventral pattern formation IMP
IMP: 通过突变表型推断
10625551 MGI
acts upstream of or within forebrain radial glial cell differentiation IMP
IMP: 通过突变表型推断
9232833 MGI
acts upstream of or within frontal suture morphogenesis IMP
IMP: 通过突变表型推断
20570969 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
23201751 MGI
acts upstream of or within heart development IGI
IGI: 通过遗传相互作用推断
11172440 MGI
acts upstream of or within hindgut morphogenesis IGI
IGI: 通过遗传相互作用推断
11485934 MGI
acts upstream of or within hippocampus development IMP
IMP: 通过突变表型推断
22235033 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
16254602 MGI
acts upstream of or within inner ear development IGI
IGI: 通过遗传相互作用推断
17395647 MGI
acts upstream of or within kidney development IGI
IGI: 通过遗传相互作用推断
11172440 MGI
acts upstream of or within lambdoid suture morphogenesis IMP
IMP: 通过突变表型推断
20570969 MGI
acts upstream of or within larynx morphogenesis IMP
IMP: 通过突变表型推断
28177282 MGI
acts upstream of or within lateral ganglionic eminence cell proliferation IMP
IMP: 通过突变表型推断
20943929 MGI
acts upstream of or within lateral semicircular canal development IMP
IMP: 通过突变表型推断
17395647 MGI
acts upstream of or within layer formation in cerebral cortex IMP
IMP: 通过突变表型推断
21525285 MGI
involved in limb development IMP
IMP: 通过突变表型推断
17400206 MGI
acts upstream of or within limb morphogenesis IMP
IMP: 通过突变表型推断
9268572 MGI
acts upstream of or within lung development IGI
IGI: 通过遗传相互作用推断
15136151 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
9268579 MGI
acts upstream of or within mammary gland development IMP
IMP: 通过突变表型推断
16914490 MGI
acts upstream of or within mammary gland specification IGI
IGI: 通过遗传相互作用推断
16720875 MGI
acts upstream of or within melanocyte differentiation IMP
IMP: 通过突变表型推断
18397875 MGI
acts upstream of or within metanephros development IGI
IGI: 通过遗传相互作用推断
16396903 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12435627 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
17400206 MGI
involved in negative regulation of alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
19667090 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
19048639 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
16396903 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
16396903 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IGI
IGI: 通过遗传相互作用推断
16284117 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: 通过突变表型推断
19048639 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
19667090 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
20570969 MGI
acts upstream of or within negative regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
20570969 MGI
involved in negative thymic T cell selection IMP
IMP: 通过突变表型推断
19667090 MGI
acts upstream of or within neural tube development IMP
IMP: 通过突变表型推断
8387379 MGI
acts upstream of neuroblast proliferation IMP
IMP: 通过突变表型推断
20943929 MGI
acts upstream of or within neuroblast proliferation IMP
IMP: 通过突变表型推断
20943929 MGI
acts upstream of neuron differentiation IMP
IMP: 通过突变表型推断
19048639 MGI
acts upstream of or within neuron fate commitment IMP
IMP: 通过突变表型推断
16168404 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
9655803 MGI
acts upstream of or within oligodendrocyte differentiation IGI
IGI: 通过遗传相互作用推断
15880651 MGI
acts upstream of or within optic nerve morphogenesis IMP
IMP: 通过突变表型推断
16342201 MGI
acts upstream of osteoblast differentiation IGI
IGI: 通过遗传相互作用推断
20570969 MGI
acts upstream of osteoblast differentiation IMP
IMP: 通过突变表型推断
20570969 MGI
acts upstream of or within pallium development IMP
IMP: 通过突变表型推断
10409502 MGI
acts upstream of or within pattern specification process IGI
IGI: 通过遗传相互作用推断
14602680 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
17328886 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11053430 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
17400206 MGI
involved in positive regulation of alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
15855276 MGI
acts upstream of or within positive regulation of chondrocyte differentiation IMP
IMP: 通过突变表型推断
17328886 MGI
acts upstream of or within positive regulation of neuroblast proliferation IMP
IMP: 通过突变表型推断
20943929 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: 通过遗传相互作用推断
20570969 MGI
acts upstream of or within positive regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
20570969 MGI
acts upstream of or within positive regulation of protein import into nucleus IGI
IGI: 通过遗传相互作用推断
17043310 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19667090 MGI
acts upstream of protein import into nucleus IGI
IGI: 通过遗传相互作用推断
17043310 MGI
acts upstream of or within protein processing IDA
IDA: 通过直接分析推断
19036983 MGI
acts upstream of or within proximal/distal pattern formation IGI
IGI: 通过遗传相互作用推断
16342201 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: 通过突变表型推断
16342201 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
9152009 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: 通过突变表型推断
8026071 MGI
acts upstream of or within regulation of bone development IMP
IMP: 通过突变表型推断
22841643 MGI
acts upstream of or within regulation of cell differentiation IGI
IGI: 通过遗传相互作用推断
16284117 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
17191253 MGI
acts upstream of or within regulation of gene expression IGI
IGI: 通过遗传相互作用推断
18799682 MGI
acts upstream of or within regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
28817564 MGI
acts upstream of or within roof of mouth development IMP
IMP: 通过突变表型推断
18816854 MGI
acts upstream of or within sagittal suture morphogenesis IMP
IMP: 通过突变表型推断
20570969 MGI
acts upstream of or within smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
12435628 MGI
involved in smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
22234993 MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning IGI
IGI: 通过遗传相互作用推断
17395647 MGI
acts upstream of or within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IGI
IGI: 通过遗传相互作用推断
15215207 MGI
acts upstream of or within smoothened signaling pathway involved in ventral spinal cord interneuron specification IGI
IGI: 通过遗传相互作用推断
15215207 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IGI
IGI: 通过遗传相互作用推断
15215207 MGI
acts upstream of or within spinal cord motor neuron differentiation IGI
IGI: 通过遗传相互作用推断
21552265 MGI
acts upstream of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
20570969 MGI
acts upstream of stem cell proliferation IMP
IMP: 通过突变表型推断
20570969 MGI
acts upstream of or within subpallium development IMP
IMP: 通过突变表型推断
20943929 MGI
acts upstream of or within telencephalon development IMP
IMP: 通过突变表型推断
10625551 MGI
involved in thymocyte apoptotic process IMP
IMP: 通过突变表型推断
19667090 MGI
acts upstream of or within tongue development IMP
IMP: 通过突变表型推断
18816854 MGI
acts upstream of or within tube development IGI
IGI: 通过遗传相互作用推断
9731531 MGI
acts upstream of or within vocalization behavior IMP
IMP: 通过突变表型推断
28177282 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axoneme IDA
IDA: 通过直接分析推断
21209331 MGI
is active in cilium IDA
IDA: 通过直接分析推断
27046536 MGI
located in cilium IDA
IDA: 通过直接分析推断
19684112 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12435627 MGI
located in nuclear speck IDA
IDA: 通过直接分析推断
19684112 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12435627 MGI
part of transcription repressor complex IDA
IDA: 通过直接分析推断
12435627 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcriptional activator GLI3

GLI3 form of 190 kDa

GLI3 full length protein

anterior digit pattern deformity

brachyphalangy

extra toes

polydactyly Nagoya

zinc finger protein GLI3

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05476 GLI3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS05482 GLIS3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21349 Gli3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27868 Gli3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gli3 NCBI NCBI:2737
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