2. Gene
  3. Got1 - glutamic-oxaloacetic transaminase 1, soluble Gene

Got1 - glutamic-oxaloacetic transaminase 1, soluble Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: cCAT; Got-1; cAspAT

基因 ID: 14718 | 基因类型: protein coding

关于 Got1

功能概要

Enables L-aspartate:2-oxoglutarate aminotransferase activity and phosphatidylserine decarboxylase activity. Acts upstream of or within several processes, including dicarboxylic acid metabolic process; fatty acid homeostasis; and glycerol biosynthetic process. Located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]

Got1 基因产物(1)

mRNA Protein Name
NM_010324.2 NP_034454.2 aspartate aminotransferase, cytoplasmic
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: 通过直接分析推断
1914521 MGI
enables phosphatidylserine decarboxylase activity IDA
IDA: 通过直接分析推断
3242498 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
25446530 MGI
acts upstream of or within aspartate biosynthetic process IDA
IDA: 通过直接分析推断
4193185 MGI
acts upstream of or within fatty acid homeostasis IDA
IDA: 通过直接分析推断
17545671 MGI
involved in gluconeogenesis IDA
IDA: 通过直接分析推断
17545671 MGI
acts upstream of or within glutamate catabolic process to aspartate IDA
IDA: 通过直接分析推断
4193185 MGI
acts upstream of or within glycerol biosynthetic process IDA
IDA: 通过直接分析推断
17545671 MGI
involved in malate-aspartate shuttle IMP
IMP: 通过突变表型推断
37813964 MGI
acts upstream of or within oxaloacetate metabolic process IDA
IDA: 通过直接分析推断
4193185 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
4193185 MGI
located in cytosol IDA
IDA: 通过直接分析推断
4193185 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aspartate aminotransferase, cytoplasmic

cysteine aminotransferase, cytoplasmic

cysteine transaminase, cytoplasmic

cytosolic aspartate aminotransferase

glutamate oxaloacetate transaminase 1, soluble

transaminase A

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0091 Adapalene 99.98% 是
HY-B0091R Adapalene (Standard) / 否
HY-B0091A Adapalene sodium salt / 否
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122723 GOT1 inhibitor-1 Inhibitor 99.45% 否
HY-160818 MC3138 Activator 99.27% 否
HY-124825 iGOT1-01 99.77% 否
HY-N6237 Aspulvinone O ≥96.0% 否
HY-RS05605 GOT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-B0091S Adapalene-d3 / 否
HY-RS05596 GOLT1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16967 Got1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23410 Got1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Got1 NCBI NCBI:2805
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