2. Gene
  3. BNIPL - BCL2 interacting protein like Gene

BNIPL - BCL2 interacting protein like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BCL2 相互作用蛋白

种属: Homo sapiens

同用名: BNIPS; PP753; BNIP-S; BNIPL1; BNIPL2; BNIPL-1; BNIPL-2; BNIP-Sbeta; BNIP-Salpha

基因 ID: 149428 | 基因类型: protein coding

关于 BNIPL

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,036,586-151,047,720 (from NCBI)

This gene has 7 transcripts (splice variants), 236 orthologues and 3 paralogues. Biased expression in skin (RPKM 64.5), esophagus (RPKM 30.1) and 1 other tissue.

功能概要

该基因编码的蛋白质与其他几种蛋白质相互作用，例如 BCL2、ARHGAP1、MIF 和 GFER。它可能作为 BCL2 和 ARHGAP1/CDC42 之间的桥梁分子，促进细胞死亡。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene interacts with several Other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

BNIPL 基因产物(2)

mRNA Protein Name
NM_001159642.2 NP_001153114.1 bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform b
NM_138278.4 NP_612122.2 bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12901880 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12681488 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic process IDA
IDA: 通过直接分析推断
11741952 GOA
involved in apoptotic process IDA
IDA: 通过直接分析推断
11741952 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
12681488 GOA
involved in regulation of growth rate IDA
IDA: 通过直接分析推断
12681488 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
11741952 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11741952 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BNIPL 蛋白结构

BNIP2

BNIP2: Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 (83 - 211)

CRAL_TRIO_2

CRAL_TRIO_2: Divergent CRAL/TRIO domain (213 - 349)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
蛋白主名 其他名称

bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

BCL2/adenovirus E1B 19kD interacting protein like

关联疾病

疾病名称 别名
Nephronophthisis 3

NPHP3

Nph3

Adolescent Nephronophthisis

Nephronophthisis, Type 3
Verrucous Papilloma
Cerebellopontine Angle Tumor

Cerebellopontine Angle Tumour

Neoplasm Of The Cerebellopontine Angle
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01566 BNIPL Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BNIPL RGD RGD:1309478
Bos taurus BNIPL VGNC VGNC:26535
Canis familiaris BNIPL VGNC VGNC:38494
Mus musculus BNIPL MGD MGI:2384749
Macaca mulatta BNIPL VGNC VGNC:70329
Felis catus BNIPL VGNC VGNC:80148
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