2. Gene
  3. Hand2 - heart and neural crest derivatives expressed 2 Gene

Hand2 - heart and neural crest derivatives expressed 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hed; Th2; dHAND; Ehand2; Thing2; bHLHa26

基因 ID: 15111 | 基因类型: protein coding

关于 Hand2

功能概要

Enables protein homodimerization activity and sequence-specific DNA binding activity. Contributes to E-box binding activity. Involved in several processes, including heart morphogenesis; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis. Acts upstream of or within several processes, including animal organ development; negative regulation of osteoblast differentiation; and nervous system development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and hindlimb phalanx. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2). [provided by Alliance of Genome Resources, Apr 2022]

Hand2 基因产物(1)

mRNA Protein Name
NM_010402.4 NP_034532.3 heart- and neural crest derivatives-expressed protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11812799 MGI
contributes to E-box binding IDA
IDA: 通过直接分析推断
11812799 MGI
enables E-box binding IDA
IDA: 通过直接分析推断
20144608 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
11812799 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10924525 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
11812799 MGI
enables sequence-specific DNA binding IGI
IGI: 通过遗传相互作用推断
12070084 MGI
contributes to transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
11812799 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
19144722 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adult heart development IMP
IMP: 通过突变表型推断
9171826 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
19341725 MGI
acts upstream of or within apoptotic process involved in heart morphogenesis IMP
IMP: 通过突变表型推断
11784028 MGI
involved in cardiac neural crest cell development involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
19008477 MGI
acts upstream of or within cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
20144608 MGI
involved in cardiac right ventricle formation IMP
IMP: 通过突变表型推断
11076755 MGI
acts upstream of or within cartilage morphogenesis IGI
IGI: 通过遗传相互作用推断
17764670 MGI
acts upstream of or within cell proliferation involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
20144608 MGI
acts upstream of or within coronary artery morphogenesis IMP
IMP: 通过突变表型推断
21350214 MGI
acts upstream of or within determination of heart left/right asymmetry IMP
IMP: 通过突变表型推断
9576835 MGI
acts upstream of or within embryonic digit morphogenesis IDA
IDA: 通过直接分析推断
12070084 MGI
involved in embryonic skeletal system development IGI
IGI: 通过遗传相互作用推断
19017795 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: 通过突变表型推断
19341725 MGI
acts upstream of or within heart development IGI
IGI: 通过遗传相互作用推断
15576406 MGI
acts upstream of or within heart looping IMP
IMP: 通过突变表型推断
9171826 MGI
acts upstream of or within heart morphogenesis IMP
IMP: 通过突变表型推断
11784028 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
9171826 MGI
acts upstream of or within mesenchymal cell proliferation IMP
IMP: 通过突变表型推断
19341725 MGI
acts upstream of or within mesenchyme development IGI
IGI: 通过遗传相互作用推断
17764670 MGI
acts upstream of or within negative regulation of DNA binding IDA
IDA: 通过直接分析推断
19144722 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
19144722 MGI
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
19008477 MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process IMP
IMP: 通过突变表型推断
19341725 MGI
acts upstream of or within negative regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
19144722 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
19144722 MGI
acts upstream of or within neural crest cell development IMP
IMP: 通过突变表型推断
9671575 MGI
acts upstream of positive effect norepinephrine biosynthetic process IMP
IMP: 通过突变表型推断
19008477 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
17764670 MGI
acts upstream of osteoblast differentiation IMP
IMP: 通过突变表型推断
19144722 MGI
involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
19008477 MGI
acts upstream of or within peripheral nervous system neuron development IDA
IDA: 通过直接分析推断
16145670 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16145670 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: 通过遗传相互作用推断
12070084 MGI
involved in positive regulation of semaphorin-plexin signaling pathway IMP
IMP: 通过突变表型推断
19008477 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11812799 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
20144608 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19008477 MGI
acts upstream of or within primary palate development IMP
IMP: 通过突变表型推断
17531968 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15351717 MGI
involved in regulation of secondary heart field cardioblast proliferation IMP
IMP: 通过突变表型推断
19008477 MGI
acts upstream of or within roof of mouth development IMP
IMP: 通过突变表型推断
17531968 MGI
acts upstream of or within suckling behavior IMP
IMP: 通过突变表型推断
17531968 MGI
acts upstream of or within sympathetic nervous system development IDA
IDA: 通过直接分析推断
16145670 MGI
involved in thymus development IMP
IMP: 通过突变表型推断
19008477 MGI
acts upstream of or within tongue development IMP
IMP: 通过突变表型推断
17531968 MGI
acts upstream of or within visceral serous pericardium development IMP
IMP: 通过突变表型推断
21350214 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
19144722 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
11812799 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

heart- and neural crest derivatives-expressed protein 2

deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2

heart and neural crest derivatives expressed transcript 2

helix-loop-helix transcription factor expressed in embryo and deciduum

thing-2

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05997 HAND2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174480 Mouse Hand2 mRNA / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hand2 NCBI NCBI:9464
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