2. Gene
  3. Hfe - homeostatic iron regulator Gene

Hfe - homeostatic iron regulator Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MR2

基因 ID: 15216 | 基因类型: protein coding

关于 Hfe

功能概要

Enables Transferrin Receptor binding activity. Involved in positive regulation of gene expression. Acts upstream of or within hormone biosynthetic process and multicellular organismal iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in brain; choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Used to study hemochromatosis type 1. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow Cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator). [provided by Alliance of Genome Resources, Apr 2022]

Hfe 基因产物(2)

mRNA Protein Name
NM_001347493.1 NP_001334422.1 hereditary hemochromatosis protein homolog isoform b precursor
NM_010424.5 NP_034554.2 hereditary hemochromatosis protein homolog isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables transferrin receptor binding IPI
IPI: 通过物理相互作用推断
16893896 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within hormone biosynthetic process IMP
IMP: 通过突变表型推断
15914561 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: 通过突变表型推断
10077651 MGI
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
24904118 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
24904118 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of HFE-transferrin receptor complex IDA
IDA: 通过直接分析推断
16893896 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hereditary hemochromatosis protein homolog

hemochromatosis

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06149 HFE Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18894 Hfe Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25385 Hfe Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hfe NCBI NCBI:3077
Macaca fascicularis Hfe NCBI NCBI:102139119
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