2. Gene
  3. Foxa1 - forkhead box A1 Gene

Foxa1 - forkhead box A1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hnf3a; Tcf3a; Hnf-3a; Tcf-3a

基因 ID: 15375 | 基因类型: protein coding

关于 Foxa1

功能概要

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including lung development; prostate gland development; and regulation of transcription by RNA polymerase II. Located in microvillus and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FOXA1 (forkhead box A1). [provided by Alliance of Genome Resources, Apr 2022]

Foxa1 基因产物(1)

mRNA Protein Name
NM_008259.4 NP_032285.2 hepatocyte nuclear factor 3-alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15485926 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
10049364 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10049364 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
22780989 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8306889 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
25446530 MGI
acts upstream of or within alveolar secondary septum development IMP
IMP: 通过突变表型推断
16214823 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: 通过遗传相互作用推断
23383217 MGI
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
15748903 MGI
acts upstream of or within connective tissue development IGI
IGI: 通过遗传相互作用推断
23383217 MGI
acts upstream of dopaminergic neuron differentiation IGI
IGI: 通过遗传相互作用推断
17596284 MGI
acts upstream of dopaminergic neuron differentiation IMP
IMP: 通过突变表型推断
17596284 MGI
acts upstream of or within dorsal/ventral neural tube patterning IGI
IGI: 通过遗传相互作用推断
23383217 MGI
acts upstream of or within epithelial cell maturation involved in prostate gland development IMP
IMP: 通过突变表型推断
15987773 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IGI
IGI: 通过遗传相互作用推断
15668254 MGI
acts upstream of or within glucose homeostasis IMP
IMP: 通过突变表型推断
10049364 MGI
acts upstream of or within hormone metabolic process IMP
IMP: 通过突变表型推断
10049364 MGI
acts upstream of or within lung development IGI
IGI: 通过遗传相互作用推断
15668254 MGI
acts upstream of or within lung epithelial cell differentiation IGI
IGI: 通过遗传相互作用推断
15668254 MGI
acts upstream of or within lung morphogenesis IMP
IMP: 通过突变表型推断
16214823 MGI
acts upstream of or within mesenchymal-epithelial cell signaling involved in prostate gland development IGI
IGI: 通过遗传相互作用推断
15987773 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17220277 MGI
acts upstream of neuron differentiation IGI
IGI: 通过遗传相互作用推断
17596284 MGI
acts upstream of neuron differentiation IMP
IMP: 通过突变表型推断
17596284 MGI
acts upstream of or within neuron fate specification IGI
IGI: 通过遗传相互作用推断
17596284 MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation IGI
IGI: 通过遗传相互作用推断
17596284 MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation IMP
IMP: 通过突变表型推断
17596284 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
23383217 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10049364 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15539431 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: 通过突变表型推断
15987773 MGI
acts upstream of or within prostate gland stromal morphogenesis IMP
IMP: 通过突变表型推断
15987773 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: 通过直接分析推断
22737085 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: 通过突变表型推断
22737085 MGI
acts upstream of or within regulation of gene expression IGI
IGI: 通过遗传相互作用推断
17596284 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16214823 MGI
acts upstream of or within respiratory basal cell differentiation IMP
IMP: 通过突变表型推断
16214823 MGI
acts upstream of or within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IMP
IMP: 通过突变表型推断
15987773 MGI
acts upstream of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
23383217 MGI
acts upstream of or within tube morphogenesis IMP
IMP: 通过突变表型推断
15987773 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in microvillus IDA
IDA: 通过直接分析推断
23266329 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8306889 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hepatocyte nuclear factor 3-alpha

HNF-3-alpha

fork head domain

forkhead box protein A1

hepatocyte nuclear factor 3 alpha (winged helix transcription factor)

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-156190A NR2F2-IN-1 free base Inhibitor 99.34% 否
HY-RS05036 FOXA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-168534 WX-02-23 99.88% 否
HY-156190 NR2F2-IN-1 Inhibitor / 否
HY-RS17339 Foxa1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23794 Foxa1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Foxa1 NCBI NCBI:3169
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