2. Gene
  3. Hnf4a - hepatic nuclear factor 4, alpha Gene

Hnf4a - hepatic nuclear factor 4, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hnf4; HNF-4; MODY1; Nr2a1; Tcf14; TCF-14; Hnf4alpha

基因 ID: 15378 | 基因类型: protein coding

关于 Hnf4a

功能概要

The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Hnf4a 基因产物(3)

mRNA Protein Name
NM_001312906.1 NP_001299835.1 hepatocyte nuclear factor 4-alpha isoform HNF4alpha11
NM_001312907.1 NP_001299836.1 hepatocyte nuclear factor 4-alpha isoform HNF4alpha10
NM_008261.3 NP_032287.2 hepatocyte nuclear factor 4-alpha isoform HNF4alpha2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15014077 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
27471003 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15761495 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10859308 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
22589549 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
17932483 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
22780989 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17636037 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8306889 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
15761495 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cholesterol homeostasis IMP
IMP: 通过突变表型推断
11158324 MGI
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
15761495 MGI
acts upstream of or within lipid metabolic process IMP
IMP: 通过突变表型推断
16498401 MGI
involved in phospholipid homeostasis IMP
IMP: 通过突变表型推断
11158324 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9408084 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
30555544 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10859308 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15761495 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17636037 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16537911 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11158324 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
9053305 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
30530698 MGI
acts upstream of or within regulation of gastrulation IMP
IMP: 通过突变表型推断
7958910 MGI
involved in regulation of insulin secretion IMP
IMP: 通过突变表型推断
15761495 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
22589549 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22589549 MGI
involved in response to glucose IMP
IMP: 通过突变表型推断
15761495 MGI
acts upstream of or within sex differentiation IMP
IMP: 通过突变表型推断
17412818 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: 通过直接分析推断
18462699 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10859308 MGI
involved in triglyceride homeostasis IMP
IMP: 通过突变表型推断
11158324 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
8306889 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hepatocyte nuclear factor 4-alpha

HNF4 alpha

Nuclear receptor 2A1

nuclear receptor subfamily 2 group A member 1

transcription factor 14

transcription factor HNF-4

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06257 HNF4A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17608 Hnf4a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06255 HNF1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24068 Hnf4a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hnf4a NCBI NCBI:3172
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