2. Gene
  3. GRK3 - G protein-coupled receptor kinase 3 Gene

GRK3 - G protein-coupled receptor kinase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体激酶 3

种属: Homo sapiens

同用名: BARK2; ADRBK2

基因 ID: 157 | 基因类型: protein coding

关于 GRK3

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:25,564,675-25,729,294 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 7 paralogues. Broad expression in fat (RPKM 17.4), spleen (RPKM 8.7) and 22 other tissues.

功能概要

β-肾上腺素能受体激酶特异性磷酸化 β-肾上腺素能和相关 G 蛋白偶联受体的激动剂占据形式。总体而言，β 肾上腺素能受体激酶 2 与 β 肾上腺素能受体激酶 1 具有 85% 的氨基酸相似性，蛋白激酶催化结构域具有 95% 的相似性。这些数据表明存在可广泛用于调节受体功能的受体激酶家族。[RefSeq 提供，2008 年 7 月]

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta Adrenergic Receptor kinase 2 has 85% amino acid similarity with beta Adrenergic Receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

GRK3 基因产物(2)

mRNA Protein Name
NM_001362778.2 NP_001349707.1 beta-adrenergic receptor kinase 2 isoform 2
NM_005160.4 NP_005151.2 beta-adrenergic receptor kinase 2 isoform 1

GRK3 蛋白结构

RGS

RGS: Regulator of G protein signaling domain (55 - 174)

Pkinase

Pkinase: Protein kinase domain (192 - 453)

PH

PH: PH domain (559 - 651)

  • 0
  • 200
  • 400
  • 600
  • 688 a.a.
蛋白主名 其他名称

beta-adrenergic receptor kinase 2

adrenergic, beta, receptor kinase 2

关联疾病

疾病名称 别名
Whim Syndrome 1

Whim Syndrome

Whims

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

WHIMS1

Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

Myelokathexis, Isolated

Wilm

Warts-Infections-Leukopenia-Myelokatexis Syndrome

Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05814 GRK3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GRK3 VGNC VGNC:62719
Bos taurus GRK3 VGNC VGNC:53904
Mus musculus GRK3 MGD MGI:87941
Rattus norvegicus GRK3 RGD RGD:2063
Macaca mulatta GRK3 VGNC VGNC:73255
Canis familiaris GRK3 VGNC VGNC:41503
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