CLEC14A - C-type lectin domain containing 14A Gene

中文名称：含 C 型凝集素结构域 14A

种属: Homo sapiens

同用名: CEG1; EGFR-5; C14orf27

关于 CLEC14A

功能概要

该基因编码 C 型凝集素/C 型凝集素样结构域 (CTL/CTLD) 超家族的成员。该家族的成员具有共同的蛋白质折叠并具有多种功能，例如细胞粘附、细胞间信号传导、糖蛋白转换以及在炎症和免疫反应中的作用。该家族成员在细胞间粘附和血管生成中发挥作用。它在丝状伪足形成、细胞迁移和管形成中起作用。由于其在肿瘤内皮中的含量高于正常组织内皮中的含量，因此被认为是肿瘤血管靶向的候选药物。[RefSeq 提供，2012 年 1 月]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]