2. Gene
  3. Irf1 - interferon regulatory factor 1 Gene

Irf1 - interferon regulatory factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Irf-1

基因 ID: 16362 | 基因类型: protein coding

关于 Irf1

功能概要

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including defense response to Other organism; regulation of T cell activation; and regulation of gene expression. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation; positive regulation of interleukin-12 production; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; lung non-small cell carcinoma; and smallpox. Orthologous to human IRF1 (interferon regulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Irf1 基因产物(3)

mRNA Protein Name
NM_001159393.1 NP_001152865.1 interferon regulatory factor 1 isoform b
NM_001159396.1 NP_001152868.1 interferon regulatory factor 1 isoform a
NM_008390.2 NP_032416.1 interferon regulatory factor 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
14568984 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
14568984 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
25774715 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
30635240 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17018642 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17159910 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within CD8-positive, alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
11359801 MGI
involved in defense response to virus IMP
IMP: 通过突变表型推断
20451243 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18641303 MGI
involved in negative regulation of regulatory T cell differentiation IMP
IMP: 通过突变表型推断
18641303 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14568984 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
20308629 MGI
acts upstream of or within positive regulation of interleukin-12 production IDA
IDA: 通过直接分析推断
14568984 MGI
acts upstream of or within positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
14568984 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17159910 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
30635240 MGI
involved in positive regulation of type I interferon production IMP
IMP: 通过突变表型推断
17018642 MGI
involved in regulation of CD8-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
21909274 MGI
involved in regulation of MyD88-dependent toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
17018642 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
11359801 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17159910 MGI
involved in type II interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
21909274 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17018642 MGI
located in nucleus IDA
IDA: 通过直接分析推断
17018642 MGI
located in nucleus IMP
IMP: 通过突变表型推断
30635240 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interferon regulatory factor 1

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-171006 IRF1-IN-1 Inhibitor 99.72% 否
HY-108052 Delphinidin 3-glucoside chloride 99.89% 否
HY-Y0148 10-Hydroxydecanoic acid Inhibitor 99.77% 否
HY-133897 (Rac)-Indoximod 99.60% 否
HY-171007 IRF1-IN-2 99.83% 否
HY-RS06902 IRF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-176222 IRF1 antagonist 1 Inhibitor / 否
HY-RS16716 Irf1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23151 Irf1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Irf1 NCBI NCBI:3659
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z