2. Gene
  3. CITED4 - Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 Gene

CITED4 - Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Cbp/p300 与富 Glu/Asp 的羧基末端结构域 4 相互作用的反式激活因子

种属: Homo sapiens

基因 ID: 163732 | 基因类型: protein coding

关于 CITED4

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,861,054-40,862,363 (from NCBI)

This gene has 1 transcript (splice variant), 228 orthologues and 2 paralogues.

功能概要

由这种无内含子基因编码的蛋白质属于 CITED 转录共激活因子家族，它通过保守的 32 aa C 末端基序与多种蛋白质结合，包括 CREB 结合蛋白 (CBP) 和 p300，并调节基因转录。该蛋白还与转录因子 AP2 (TFAP2) 相互作用，因此可能作为 TFAP2 的共激活因子发挥作用。已在染色体臂 1p 和 19q 缺失的少突胶质细胞肿瘤中观察到该基因的超甲基化和转录下调，并且与少突胶质细胞肿瘤患者的无复发生存期和总生存期更长相关。[RefSeq 提供，2011 年 8 月]

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]

CITED4 基因产物(1)

mRNA Protein Name
NM_133467.3 NP_597724.1 cbp/p300-interacting transactivator 4

CITED4 蛋白结构

CITED

CITED: CITED (1 - 184)

  • 0
  • 100
  • 184 a.a.
蛋白主名 其他名称

cbp/p300-interacting transactivator 4

MRG-2

关联疾病

疾病名称 别名
Adult Oligodendroglioma

Adult Brain Oligodendroglioma

Grade Ii Adult Oligodendroglial Tumor

Oligodendroglioma, Adult
Photoallergic Dermatitis

Dermatitis, Photoallergic

Photoallergic Contact Dermatitis

Photoallergic Eczema

Photo-Allergic Contact Eczema
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02730 CITED4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CITED4 VGNC VGNC:27378
Rattus norvegicus CITED4 RGD RGD:620113
Macaca mulatta CITED4 VGNC VGNC:99867
Mus musculus CITED4 MGD MGI:1861694
Felis catus CITED4 VGNC VGNC:107511
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z