2. Gene
  3. Kcnq2 - potassium voltage-gated channel, subfamily Q, member 2 Gene

Kcnq2 - potassium voltage-gated channel, subfamily Q, member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: KQT2; HNSPC; Nmf134

基因 ID: 16536 | 基因类型: protein coding

关于 Kcnq2

功能概要

Enables Calmodulin binding activity and voltage-gated ion channel activity. Acts upstream of or within membrane hyperpolarization and transmission of nerve impulse. Located in cell surface; main axon; and plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including brain; gut; immune system; reproductive system; and white fat. Used to study benign neonatal seizures and developmental and epileptic encephalopathy 7. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq2 基因产物(7)

mRNA Protein Name
NM_001003824.2 NP_001003824.1 potassium voltage-gated channel subfamily KQT member 2 isoform 2
NM_001003825.3 NP_001003825.1 potassium voltage-gated channel subfamily KQT member 2 isoform 3
NM_001006668.2 NP_001006669.1 potassium voltage-gated channel subfamily KQT member 2 isoform 4
NM_001006669.2 NP_001006670.1 potassium voltage-gated channel subfamily KQT member 2 isoform 5
NM_001006674.2 NP_001006675.1 potassium voltage-gated channel subfamily KQT member 2 isoform 6
NM_001302888.1 NP_001289817.1 potassium voltage-gated channel subfamily KQT member 2 isoform 13
NM_010611.3 NP_034741.2 potassium voltage-gated channel subfamily KQT member 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calmodulin binding IMP
IMP: 通过突变表型推断
24333508 MGI
enables calmodulin binding IPI
IPI: 通过物理相互作用推断
12223552 MGI
enables potassium channel activity IGI
IGI: 通过遗传相互作用推断
23716673 MGI
enables potassium channel activity IMP
IMP: 通过突变表型推断
14762142 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14762142 MGI
enables voltage-gated monoatomic ion channel activity IGI
IGI: 通过遗传相互作用推断
12223552 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within action potential IDA
IDA: 通过直接分析推断
14762142 MGI
acts upstream of or within action potential IMP
IMP: 通过突变表型推断
14762142 MGI
acts upstream of or within action potential initiation IDA
IDA: 通过直接分析推断
26312501 MGI
acts upstream of or within action potential initiation IGI
IGI: 通过遗传相互作用推断
23716673 MGI
acts upstream of or within action potential initiation IMP
IMP: 通过突变表型推断
24719109 MGI
acts upstream of or within apoptosome assembly IMP
IMP: 通过突变表型推断
20885443 MGI
acts upstream of or within behavior IMP
IMP: 通过突变表型推断
15608631 MGI
acts upstream of or within brain development IMP
IMP: 通过突变表型推断
30382937 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: 通过直接分析推断
23259949 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
23259949 MGI
acts upstream of or within cognition IMP
IMP: 通过突变表型推断
15608631 MGI
acts upstream of or within dentate gyrus development IGI
IGI: 通过遗传相互作用推断
16464983 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: 通过遗传相互作用推断
21156207 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: 通过突变表型推断
24719109 MGI
acts upstream of or within endocytosis IMP
IMP: 通过突变表型推断
21466805 MGI
acts upstream of or within establishment of cell polarity IMP
IMP: 通过突变表型推断
24719109 MGI
acts upstream of or within excitatory chemical synaptic transmission IDA
IDA: 通过直接分析推断
14762142 MGI
acts upstream of or within excitatory chemical synaptic transmission IGI
IGI: 通过遗传相互作用推断
30382937 MGI
acts upstream of or within exocytosis IMP
IMP: 通过突变表型推断
21466805 MGI
acts upstream of or within exploration behavior IMP
IMP: 通过突变表型推断
31283873 MGI
acts upstream of or within gene expression IDA
IDA: 通过直接分析推断
24333508 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
18483067 MGI
acts upstream of or within grooming behavior IMP
IMP: 通过突变表型推断
31283873 MGI
acts upstream of or within hippocampal pyramidal neuron differentiation IMP
IMP: 通过突变表型推断
15608631 MGI
acts upstream of or within hippocampus development IMP
IMP: 通过突变表型推断
15608631 MGI
acts upstream of or within inhibitory chemical synaptic transmission IGI
IGI: 通过遗传相互作用推断
30382937 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
32239694 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
15608631 MGI
acts upstream of or within mitochondrial depolarization IMP
IMP: 通过突变表型推断
20885443 MGI
acts upstream of or within monoatomic ion transmembrane transport IMP
IMP: 通过突变表型推断
18483067 MGI
acts upstream of or within motor behavior IMP
IMP: 通过突变表型推断
19453707 MGI
acts upstream of or within nerve development IGI
IGI: 通过遗传相互作用推断
16464983 MGI
acts upstream of or within nerve development IMP
IMP: 通过突变表型推断
18483067 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: 通过突变表型推断
20885443 MGI
acts upstream of or within neuron differentiation IMP
IMP: 通过突变表型推断
21466805 MGI
acts upstream of or within neuron remodeling IGI
IGI: 通过遗传相互作用推断
30382937 MGI
acts upstream of or within neuronal action potential IMP
IMP: 通过突变表型推断
24719109 MGI
acts upstream of or within protein import into nucleus IMP
IMP: 通过突变表型推断
20885443 MGI
acts upstream of or within protein phosphorylation IMP
IMP: 通过突变表型推断
21466805 MGI
acts upstream of or within protein transport IMP
IMP: 通过突变表型推断
20885443 MGI
acts upstream of or within psychomotor behavior IMP
IMP: 通过突变表型推断
19453707 MGI
acts upstream of or within regulation of action potential firing threshold IGI
IGI: 通过遗传相互作用推断
23716673 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: 通过突变表型推断
15608631 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
18483067 MGI
acts upstream of or within response to auditory stimulus IDA
IDA: 通过直接分析推断
26312501 MGI
acts upstream of or within response to auditory stimulus IGI
IGI: 通过遗传相互作用推断
23716673 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: 通过突变表型推断
24687876 MGI
acts upstream of or within response to organic cyclic compound IDA
IDA: 通过直接分析推断
20885443 MGI
acts upstream of or within response to temperature stimulus IMP
IMP: 通过突变表型推断
24687876 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
14762142 MGI
acts upstream of or within sensory perception of sound IGI
IGI: 通过遗传相互作用推断
23716673 MGI
acts upstream of or within social behavior IMP
IMP: 通过突变表型推断
31283873 MGI
acts upstream of or within sodium ion transmembrane transport IGI
IGI: 通过遗传相互作用推断
16464983 MGI
acts upstream of or within substantia propria of cornea development IMP
IMP: 通过突变表型推断
19453707 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: 通过突变表型推断
10854243 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in axon initial segment IDA
IDA: 通过直接分析推断
14762142 MGI
located in axon initial segment IDA
IDA: 通过直接分析推断
16525039 MGI
located in cell surface IDA
IDA: 通过直接分析推断
12223552 MGI
is active in node of Ranvier IDA
IDA: 通过直接分析推断
14762142 MGI
located in node of Ranvier IDA
IDA: 通过直接分析推断
16525039 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16525039 MGI
part of voltage-gated potassium channel complex IGI
IGI: 通过遗传相互作用推断
12223552 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

potassium voltage-gated channel subfamily KQT member 2

KQT-like 2

potassium channel subunit alpha KvLQT2

voltage-gated potassium channel subunit Kv7.2

相关产品

Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108577 XE991 dihydrochloride Inhibitor 99.63% 否
HY-122114 ICA-27243 Activator 99.27% 否
HY-113616A VU0364572 TFA Agonist 99.27% 否
HY-101396 ICA-069673 Activator 99.20% 否
HY-145016 HN37 Activator 99.53% 否
HY-157485 Ebio1 Activator 99.99% 否
HY-108577A XE991 Inhibitor 99.69% 否
HY-108587 ICA 110381 Modulator 99.85% 否
HY-18063 ML252 Inhibitor 99.65% 否
HY-123264 RL648_81 Inhibitor 99.20% 否
HY-113616 VU0364572 Agonist / 否
HY-130070 QO-40 Activator 98.77% 否
HY-168214 Kv7.2/Kv7.3 agonist 1 Inhibitor / 否
HY-172140 Ebio3 Inhibitor / 否
HY-172141 Ebio2 Activator / 否
HY-RS07174 KCNQ2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-115823 ztz240 / 否
HY-18063A ML252 hydrochloride Inhibitor / 否
HY-RS17110 Kcnq2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23555 Kcnq2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kcnq2 NCBI NCBI:3785
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