2. Gene
  3. Krt1 - keratin 1 Gene

Krt1 - keratin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Krt86; Krt2-1; Krt-2.1

基因 ID: 16678 | 基因类型: protein coding

关于 Krt1

功能概要

Predicted to enable carbohydrate binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Acts upstream of or within establishment of skin barrier and negative regulation of inflammatory response. Located in keratin filament. Is expressed in autopod; nose; skin; and tongue. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis; epidermolytic palmoplantar keratoderma; and nonepidermolytic palmoplantar keratoderma. Orthologous to human KRT1 (keratin 1). [provided by Alliance of Genome Resources, Apr 2022]

Krt1 基因产物(1)

mRNA Protein Name
NM_008473.2 NP_032499.2 keratin, type II cytoskeletal 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11408584 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within establishment of skin barrier IMP
IMP: 通过突变表型推断
23132931 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
23132931 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
23132931 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cornified envelope IDA
IDA: 通过直接分析推断
26644517 MGI
located in keratin filament IDA
IDA: 通过直接分析推断
2404337 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

keratin, type II cytoskeletal 1

67 kDa cytokeratin

CK-1

K1

cytokeratin-1

keratin 86

keratin complex 2, basic, gene 1

type-II keratin Kb1

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10789 P160 peptide Inhibitor / 否
HY-P10790 Breast cancer targeting peptide 18–4 Inhibitor / 否
HY-RS07433 KRT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19346 Krt1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25837 Krt1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Krt1 NCBI NCBI:3848
Canis familiaris Krt1 NCBI NCBI:444857
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