DEFA3 - defensin alpha 3 Gene

中文名称：防御素α3

种属: Homo sapiens

同用名: HP3; DEF3; HNP3; HP-3; HNP-3

关于 DEFA3

功能概要

防御素是一类被认为参与宿主防御的抗菌和细胞毒性肽。它们大量存在于中性粒细胞颗粒中，也存在于粘膜表面的上皮细胞中，例如肠道、呼吸道、泌尿道和阴道。防御素家族的成员在蛋白质序列上高度相似，并以保守的半胱氨酸基序为特征。由该基因编码的蛋白质防御素 alpha 3 存在于嗜中性粒细胞的杀微生物颗粒中，可能在吞噬细胞介导的宿主防御中发挥作用。几个 alpha 防御素基因聚集在 8 号染色体上。该基因与防御素 alpha 1 仅一个氨基酸不同。该基因和编码防御素的基因 alpha 1 都存在拷贝数变异。[RefSeq 提供，2014 年 10 月]

Defensins are a family of antimicrobial and cytotoxic Peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014]