DFFA - DNA fragmentation factor subunit alpha Gene

中文名称：DNA 片段化因子亚基 α

种属: Homo sapiens

同用名: DFF1; ICAD; DFF-45

关于 DFFA

功能概要

细胞凋亡是一种细胞死亡过程，可在哺乳动物发育过程中去除有毒和/或无用的细胞。细胞凋亡过程伴随着细胞和细胞核的收缩和破碎以及染色体 DNA 降解为核小体单位。 DNA 片段化因子 (DFF) 是 40-kD (DFFB) 和 45-kD (DFFA) 亚基的异二聚体蛋白。 DFFA 是 Caspase-3 的底物，在细胞凋亡过程中触发 DNA 片段化。当 DFFA 被 Caspase-3 切割时，DFF 被激活。 DFFA 的切割片段从 DFFB (DFF 的活性成分) 解离。已发现 DFFB 在细胞凋亡过程中触发 DNA 片段化和染色质浓缩。已经为该基因发现了编码不同亚型的两个可变剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for Caspase-3 and triggers DNA fragmentation during Apoptosis. DFF becomes activated when DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during Apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]