1. Gene
  2. DACT2 - dishevelled binding antagonist of beta catenin 2 Gene

DACT2 - dishevelled binding antagonist of beta catenin 2 Gene

中文名称:连环蛋白 2 的散乱结合拮抗因子

种属: Homo sapiens

同用名: DPR2; DAPPER2; C6orf116; bA503C24.7

基因 ID: 168002 | 基因类型: protein coding

关于 DACT2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:168,292,830-168,319,777 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 2 paralogues. Biased expression in placenta (RPKM 6.6), prostate (RPKM 2.5) and 8 other tissues.

功能概要

预计将启用多种功能,包括 β-连环蛋白结合活性; δ-连环蛋白结合活性;和蛋白激酶 C 结合活性。预计参与多个过程,包括上皮细胞形态发生;内髓集合管发育;和节点信号通路的负调控。预测作用于造血祖细胞分化的上游或内部。预计在细胞质中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including epithelial cell morphogenesis; inner medullary collecting duct development; and negative regulation of nodal signaling pathway. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DACT2 基因产物(3)

mRNA Protein Name
NM_001286350.2 NP_001273279.1 dapper homolog 2 isoform b
NM_001286351.2 NP_001273280.1 dapper homolog 2 isoform c
NM_214462.5 NP_999627.2 dapper homolog 2 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DACT2 蛋白结构

Dapper

Dapper: Dapper (20 - 774)

  • 0
  • 200
  • 400
  • 600
  • 774 a.a.
蛋白主名 其他名称

dapper homolog 2

dapper antagonist of catenin 2

关联疾病

疾病名称 别名
Extraocular Retinoblastoma

Pediatric Extraocular Retinoblastoma

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DACT2 RGD RGD:1310742
Macaca mulatta DACT2 VGNC VGNC:71688
Bos taurus DACT2 VGNC VGNC:27868
Mus musculus DACT2 MGD MGI:1920347
Canis familiaris DACT2 VGNC VGNC:39762