Lef1 - lymphoid enhancer binding factor 1 Gene

种属: Mus musculus

同用名: Lef-1; 3000002B05

基因 ID: 16842 | 基因类型: protein coding

关于 Lef1

功能概要

Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including T-helper 1 cell differentiation; positive regulation of gamma-delta T cell differentiation; and secondary palate development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of beta-catenin-TCF complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in ovarian Cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Lef1 基因产物(7)

mRNA	Protein	Name
NM_001276402.2	NP_001263331.1	lymphoid enhancer-binding factor 1 isoform b
NM_001276403.1	NP_001263332.1	lymphoid enhancer-binding factor 1 isoform c
NM_001379059.1	NP_001365988.1	lymphoid enhancer-binding factor 1 isoform d
NM_001379060.1	NP_001365989.1	lymphoid enhancer-binding factor 1 isoform e
NM_001379061.1	NP_001365990.1	lymphoid enhancer-binding factor 1 isoform f
NM_001379062.1	NP_001365991.1	lymphoid enhancer-binding factor 1 isoform g
NM_010703.5	NP_034833.2	lymphoid enhancer-binding factor 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	7774816	MGI
enables DNA binding, bending	EXP EXP: 通过实验结果推断	15236581	MGI
enables DNA binding, bending	IDA IDA: 通过直接分析推断	7774816	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	12244173	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	11696550	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI IGI: 通过遗传相互作用推断	15729346	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	30659184	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	12244173	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	15024079	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	15545629	MGI
enables nucleic acid binding	EXP EXP: 通过实验结果推断	15236581	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	11696550	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	21750544	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	7537238	MGI
enables transcription factor binding	IPI IPI: 通过物理相互作用推断	12551949	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within B cell proliferation	IMP IMP: 通过突变表型推断	10933391	MGI
acts upstream of or within BMP signaling pathway	IDA IDA: 通过直接分析推断	9769173	MGI
acts upstream of or within T cell receptor V(D)J recombination	IGI IGI: 通过遗传相互作用推断	9462507	MGI
involved in T-helper 1 cell differentiation	IDA IDA: 通过直接分析推断	18579517	MGI
acts upstream of or within alpha-beta T cell differentiation	IGI IGI: 通过遗传相互作用推断	9462507	MGI
acts upstream of or within anatomical structure regression	IMP IMP: 通过突变表型推断	16163358	MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis	IMP IMP: 通过突变表型推断	16163358	MGI
acts upstream of or within apoptotic process involved in morphogenesis	IMP IMP: 通过突变表型推断	15649466	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: 通过突变表型推断	19154719	MGI
involved in canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	9769173	MGI
involved in canonical Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	10933391	MGI
involved in canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	16678815	MGI
acts upstream of or within cell development	IGI IGI: 通过遗传相互作用推断	15729346	MGI
acts upstream of or within chorio-allantoic fusion	IGI IGI: 通过遗传相互作用推断	10090727	MGI
acts upstream of or within dentate gyrus development	IMP IMP: 通过突变表型推断	10631168	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: 通过遗传相互作用推断	10090727	MGI
acts upstream of or within epithelial cell apoptotic process	IMP IMP: 通过突变表型推断	15649466	MGI
involved in epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	14691138	MGI
acts upstream of or within face morphogenesis	IGI IGI: 通过遗传相互作用推断	17699607	MGI
acts upstream of or within forebrain neuroblast division	IGI IGI: 通过遗传相互作用推断	14715945	MGI
acts upstream of or within forebrain radial glial cell differentiation	IGI IGI: 通过遗传相互作用推断	14715945	MGI
acts upstream of or within formation of radial glial scaffolds	IGI IGI: 通过遗传相互作用推断	14715945	MGI
acts upstream of or within hippocampus development	IMP IMP: 通过突变表型推断	10631168	MGI
acts upstream of or within mammary gland development	IMP IMP: 通过突变表型推断	16678815	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12551949	MGI
acts upstream of or within negative regulation of striated muscle tissue development	IDA IDA: 通过直接分析推断	16936075	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16678101	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: 通过遗传相互作用推断	17699607	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: 通过突变表型推断	12502739	MGI
acts upstream of or within paraxial mesoderm formation	IGI IGI: 通过遗传相互作用推断	10090727	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	10631168	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	10933391	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IMP IMP: 通过突变表型推断	30659184	MGI
acts upstream of or within positive regulation of chondrocyte proliferation	IMP IMP: 通过突变表型推断	30659184	MGI
involved in positive regulation of gamma-delta T cell differentiation	IMP IMP: 通过突变表型推断	23562159	MGI
involved in positive regulation of odontoblast differentiation	IMP IMP: 通过突变表型推断	29148101	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12475749	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12244173	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	15094381	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	20371816	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17284610	MGI
involved in regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	23562159	MGI
acts upstream of or within regulation of Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	10090727	MGI
acts upstream of or within regulation of cell-cell adhesion	IMP IMP: 通过突变表型推断	19154719	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11696550	MGI
involved in secondary palate development	IMP IMP: 通过突变表型推断	14691138	MGI
acts upstream of or within sensory perception of taste	IMP IMP: 通过突变表型推断	17284610	MGI
acts upstream of or within somitogenesis	IGI IGI: 通过遗传相互作用推断	10090727	MGI
acts upstream of or within somitogenesis	IMP IMP: 通过突变表型推断	15545629	MGI
acts upstream of or within sprouting angiogenesis	IMP IMP: 通过突变表型推断	19154719	MGI
acts upstream of or within tongue development	IMP IMP: 通过突变表型推断	17284610	MGI
acts upstream of or within trachea gland development	IMP IMP: 通过突变表型推断	10498680	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17284610	MGI
acts upstream of or within vasculature development	IMP IMP: 通过突变表型推断	16163358	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	21075118	MGI
part of beta-catenin-TCF complex	IDA IDA: 通过直接分析推断	20371816	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	14623238	MGI
located in nucleus	IDA IDA: 通过直接分析推断	7537238	MGI
is active in nucleus	IPI IPI: 通过物理相互作用推断	30659184	MGI
part of transcription regulator complex	IDA IDA: 通过直接分析推断	30659184	MGI
part of transcription regulator complex	IPI IPI: 通过物理相互作用推断	11696550	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

lymphoid enhancer-binding factor 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07584	LEF1 Human Pre-designed siRNA Set A	Pre-designed Set	≥90.0%	否
HY-RS18620	Lef1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25106	Lef1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Lef1	NCBI	NCBI:51176

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Lef1 - lymphoid enhancer binding factor 1 Gene

关于 Lef1

功能概要

Lef1 基因产物(7)

直系同源

热门区域

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Lef1 - lymphoid enhancer binding factor 1 Gene

关于 Lef1

功能概要

Lef1 基因产物(7)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z