Lrp5 - low density lipoprotein receptor-related protein 5 Gene

种属: Mus musculus

同用名: HBM; LR3; LRP7; OPPG; BMND1; mKIAA4142

关于 Lrp5

功能概要

Enables Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; positive regulation of osteoblast differentiation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including embryonic morphogenesis; mammary gland development; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Apr 2022]