DHX36 - DEAH-box helicase 36 Gene

中文名称：DEAH 盒解旋酶 36

种属: Homo sapiens

同用名: G4R1; RHAU; DDX36; MLEL1

关于 DHX36

功能概要

该基因是 RNA 依赖性 NTPases 的 DEAH-box 家族成员，以基序 II 中的保守氨基酸序列 Asp-Glu-Ala-His 命名。该基因编码的蛋白质已被证明可以增强具有 3'-UTR AU 富集元素 (ARE-mRNA) 的 mRNA 的去腺苷酸化和衰变。该蛋白质还被证明可以将高度稳定的四分子 DNA 配置 (G4) 分解成单链，这种配置可以在富含鸟嘌呤的 DNA 区域自发形成。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]