2. Gene
  3. Ilk - integrin-linked kinase Gene

Ilk - integrin-linked kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ILK-1; ILK-2; p59ILK

基因 ID: 170922 | 基因类型: protein coding

关于 Ilk

功能概要

Enables SH3 domain binding activity; Integrin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process; nervous system development; and regulation of protein kinase activity. Located in several cellular components, including costamere; dendritic shaft; and focal adhesion. Part of protein-containing complex. Colocalizes with stress fiber. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ILK (Integrin linked kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ilk 基因产物(1)

mRNA Protein Name
NM_133409.2 NP_596900.1 integrin-linked protein kinase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IDA
IDA: 通过直接分析推断
18252715 RGD
enables integrin binding IPI
IPI: 通过物理相互作用推断
11133699 RGD
enables protein domain specific binding IDA
IDA: 通过直接分析推断
11304546 RGD
enables protein kinase activity IDA
IDA: 通过直接分析推断
18535176 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
17167118 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
16170337 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
12629168 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
16941698 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
16170337 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
12629168 RGD
involved in negative regulation of protein kinase activity IMP
IMP: 通过突变表型推断
12629168 RGD
involved in negative regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
18535176 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
18535176 RGD
involved in neuron projection morphogenesis IMP
IMP: 通过突变表型推断
12629168 RGD
involved in positive regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
17182785 RGD
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
16941698 RGD
involved in positive regulation of axon extension IMP
IMP: 通过突变表型推断
17490631 RGD
involved in positive regulation of axonogenesis IMP
IMP: 通过突变表型推断
17490631 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
16941698 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
16941698 RGD
involved in positive regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
18535176 RGD
involved in positive regulation of cellular senescence IMP
IMP: 通过突变表型推断
17234816 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
17182785 RGD
involved in positive regulation of myoblast differentiation IMP
IMP: 通过突变表型推断
14550274 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
16941698 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
18535176 RGD
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
17234816 RGD
involved in regulation of cell growth IMP
IMP: 通过突变表型推断
16170337 RGD
involved in substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
16941698 RGD
involved in supramolecular fiber organization IMP
IMP: 通过突变表型推断
17234816 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
17490631 RGD
located in cell-cell junction IDA
IDA: 通过直接分析推断
11133699 RGD
located in costamere IDA
IDA: 通过直接分析推断
16170337 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
17490631 RGD
located in focal adhesion IDA
IDA: 通过直接分析推断
11304546 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
17490631 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
16170337 RGD
located in stress fiber IDA
IDA: 通过直接分析推断
18535176 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
17490631 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integrin-linked protein kinase

59 kDa serine/threonine-protein kinase

beta-integrin-linked kinase

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18676 OSU-T315 99.88% 否
HY-113439 12-HETE Inhibitor 95.70% 否
HY-115677 ILK-IN-3 Inhibitor 99.62% 否
HY-18676B ILK-IN-2 99.41% 否
HY-113439S 12-HETE-d8 Inhibitor ≥98.0% 否
HY-RS06787 ILK Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16756 Ilk Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23195 Ilk Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ilk NCBI NCBI:3611
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z