2. Gene
  3. Pde5a - phosphodiesterase 5A Gene

Pde5a - phosphodiesterase 5A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 5A

种属: Rattus norvegicus

同用名: PDE5A2

基因 ID: 171115 | 基因类型: protein coding

关于 Pde5a

Primary_assembly 2: 210,858,063-210,999,701 forward strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 17 phenotypes. Biased expression in Lung (RPKM 466.), Brain (RPKM 88.6) and 6 other tissues.

功能概要

该基因编码的蛋白可启动 3',5'-环状 GMP 磷酸二酯酶活性。参与多个过程，包括维持血管直径；对睾酮的反应；和短期记忆。位于胞质溶胶中。用于研究动脉疾病（多种）；阳痿（多次）；和原发性胆汁性胆管炎。该基因的人类直系同源物与 IgA 肾小球肾炎有关。与人 PDE5A（磷酸二酯酶 5A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including blood vessel diameter maintenance; response to testosterone; and short-term memory. Located in cytosol. Used to study artery disease (multiple); impotence (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A). [provided by Alliance of Genome Resources, Apr 2022]

Pde5a 基因产物(1)

mRNA Protein Name
NM_133584.1 NP_598268.1 cGMP-specific 3',5'-cyclic phosphodiesterase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
15100365 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in nervous system development IEP
IEP: 通过表达模式推断
9370351 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
19474186 RGD
involved in positive regulation of chronic inflammatory response IMP
IMP: 通过突变表型推断
19129291 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
19542492 RGD
involved in regulation of the force of heart contraction IMP
IMP: 通过突变表型推断
17606845 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
12466227 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
17141339 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
17138653 RGD
involved in short-term memory IMP
IMP: 通过突变表型推断
19129291 RGD
involved in vasodilation IEP
IEP: 通过表达模式推断
16545481 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pde5a 蛋白结构

GAF

GAF: smart00065 (153 - 310)

GAF

GAF: smart00065 (336 - 502)

PDEase_I

PDEase_I: pfam00233 (601 - 835)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 865 a.a.
蛋白主名 其他名称

cGMP-specific 3',5'-cyclic phosphodiesterase

CGB-PDE

cGMP-binding cGMP specific phosphodiesterase 5A2

cGMP-binding cGMP-specific phosphodiesterase

phosphodiesterase 5A, cGMP-specific

phosphodiesterase type 5

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-170435 PDE5-IN-13 Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-106230A Dasantafil Inhibitor 98.35% 否
HY-N1343 Robustine Inhibitor 99.95% 否
HY-161851 MDL3 Inhibitor / 否
HY-RS10227 PDE5A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10228 Pde5a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10229 Pde5a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde5a NCBI NCBI:8654
Mus musculus Pde5a NCBI NCBI:242202
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