1. Gene
  2. PTCRA - pre T cell antigen receptor alpha Gene

PTCRA - pre T cell antigen receptor alpha Gene

中文名称:前 T 细胞抗原受体α

种属: Homo sapiens

同用名: PTA; PT-ALPHA

基因 ID: 171558 | 基因类型: protein coding

关于 PTCRA

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,916,053-42,925,838 (from NCBI)

This gene has 4 transcripts (splice variants) and 84 orthologues. Biased expression in spleen (RPKM 1.2), lymph node (RPKM 0.8) and 5 other tissues.

功能概要

由该基因编码的蛋白质是单程 I 型膜蛋白,存在于未成熟但不成熟的 T 细胞中。与 TCRB 和 CD3 复合物一起,编码的蛋白质形成前 T 细胞受体复合物,调节早期 T 细胞发育。已为该基因发现编码不同亚型的四种转录变体。[RefSeq 提供,2011 年 7 月]

The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PTCRA 基因产物(4)

mRNA Protein Name
NM_001243168.2 NP_001230097.1 pre T-cell antigen receptor alpha isoform 1 precursor
NM_001243169.2 NP_001230098.1 pre T-cell antigen receptor alpha isoform 3 precursor
NM_001243170.2 NP_001230099.1 pre T-cell antigen receptor alpha isoform 4 precursor
NM_138296.3 NP_612153.2 pre T-cell antigen receptor alpha isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22795130 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PTCRA 蛋白结构

PTCRA

PTCRA: Pre-T-cell antigen receptor (20 - 173)

  • 0
  • 100
  • 200
  • 281 a.a.
蛋白主名 其他名称

pre T-cell antigen receptor alpha

pT-alpha-TCR

关联疾病

疾病名称 别名
Immunodeficiency 19

IMD19

Cd3-Delta Deficiency

Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive

Cd3delta Deficiency

Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive

Immunodeficiency 19, Severe Combined

Cd3d

Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive

T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid

T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency

Immunodeficiency, Type 19

Immunodeficiency 18

IMD18

Cd3-Epsilon Deficiency

Immunodeficiency 18, Scid Variant

Cd3epsilon Deficiency

Immunodeficiency 18, Severe Combined Immunodeficiency Variant

Immunodeficiency, Type 18

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus PTCRA VGNC VGNC:64426
Bos taurus PTCRA VGNC VGNC:33494
Macaca mulatta PTCRA VGNC VGNC:76298
Canis familiaris PTCRA VGNC VGNC:54346
Rattus norvegicus PTCRA RGD RGD:621388
Mus musculus PTCRA MGD MGI:104857