Mc3r - melanocortin 3 receptor Gene

中文名称：黑皮质素 3 受体

种属: Mus musculus

同用名: MC3-R

关于 Mc3r

功能概要

该基因编码黑皮质素受体家族的一个成员。黑皮质素受体是跨膜 G 蛋白偶联受体，它对小肽激素有反应，并表现出多种功能和组织类型定位。作为中枢神经黑皮质素系统的一部分，编码的蛋白质与促黑素细胞激素或刺豚鼠相关蛋白竞争性结合，以调节能量稳态和适应食物限制。该基因的破坏会导致体重增加与食物摄入量的比率增加、脂肪量增加和瘦体重减少，而不会对胰岛素敏感性或葡萄糖代谢产生大的影响。 [RefSeq 提供，2012 年 12 月]

This gene encodes a member of the Melanocortin Receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide Hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis and adaptation to food restriction. Disruption of this gene results in an increased ratio of weight gain to food intake, increased fat mass, and decreased lean mass, without having a large effect on Insulin sensitivity or glucose metabolism. [provided by RefSeq, Dec 2012]