Mmp8 - matrix metallopeptidase 8 Gene

中文名称：基质金属肽酶 8

种属: Mus musculus

关于 Mmp8

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员，这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解处理，产生成熟的锌依赖性内肽酶，可降解 I、II 和 III 型胶原蛋白。缺乏编码蛋白的小鼠在对各种药物的炎症反应中表现出异常。该基因位于 9 号染色体上的其他基质金属蛋白酶基因簇中。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]