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  2. Mmp8 - matrix metallopeptidase 8 Gene

Mmp8 - matrix metallopeptidase 8 Gene

中文名称:基质金属肽酶 8

种属: Mus musculus

基因 ID: 17394 | 基因类型: protein coding

关于 Mmp8

Chromosome 9: 7,558,457-7,568,486 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 111 orthologues, 23 paralogues and is associated with 10 phenotypes. Biased expression in liver E18 (RPKM 19.) and liver E14.5 (RPKM .8).

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员,这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解处理,产生成熟的锌依赖性内肽酶,可降解 I、II 和 III 型胶原蛋白。缺乏编码蛋白的小鼠在对各种药物的炎症反应中表现出异常。该基因位于 9 号染色体上的其他基质金属蛋白酶基因簇中。[RefSeq 提供,2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]

Mmp8 基因产物(1)

mRNA Protein Name
NM_008611.4 NP_032637.3 neutrophil collagenase preproprotein

Mmp8 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (30 - 85)

Peptidase_M10

Peptidase_M10: pfam00413 (106 - 261)

HX

HX: cd00094 (275 - 463)

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  • 465 a.a.
蛋白主名 其他名称

neutrophil collagenase

collagenase-2

matrix metalloproteinase-8

重组 Mmp8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73808 MMP-8 Protein, Mouse (HEK293) O70138 (F21-S465) ≥95%
HY-P73809 MMP-8 Protein, Mouse (CHO, His) O70138 (M1-S465) ≥95%
HY-P78328 MMP-8 Protein, Mouse (HEK293, His) O70138 (F21-S465) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp8 NCBI NCBI:4317
Macaca fascicularis Mmp8 NCBI NCBI:102141209