2. Gene
  3. Mthfr - methylenetetrahydrofolate reductase Gene

Mthfr - methylenetetrahydrofolate reductase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 17769 | 基因类型: protein coding

关于 Mthfr

功能概要

Enables methylenetetrahydrofolate reductase (NAD(P)H) activity. Acts upstream of or within methionine biosynthetic process. Predicted to be located in synapse. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; cranium; heart; sensory organ; and testis. Used to study neural tube defect. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic Cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Apr 2022]

Mthfr 基因产物(2)

mRNA Protein Name
NM_001161798.1 NP_001155270.1 methylenetetrahydrofolate reductase isoform a
NM_010840.3 NP_034970.2 methylenetetrahydrofolate reductase isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IMP
IMP: 通过突变表型推断
15217352 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within methionine biosynthetic process IMP
IMP: 通过突变表型推断
15217352 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

methylenetetrahydrofolate reductase

5,10-methylenetetrahydrofolate reductase

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08778 MTHFR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20057 Mthfr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26561 Mthfr Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mthfr NCBI NCBI:4524
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