Mttp - microsomal triglyceride transfer protein Gene

中文名称：微粒体甘油三酯转移蛋白

种属: Mus musculus

同用名: MTP; 1810043K16Rik

关于 Mttp

功能概要

该基因编码的蛋白促进胆固醇转移活动；磷脂酰乙醇胺转移活性；和甘油三酯转移活性。作用于多个过程的上游或内部，包括胆固醇稳态；脂蛋白转运；和低密度脂蛋白颗粒重塑。位于高尔基体和内质网中。在肠道中表达；肝;胎盘;横隔肝成分；和卵黄囊。该基因的人类直系同源物与多种疾病有关，包括腹部肥胖代谢综合征 1；无β脂蛋白血症；家族性高胆固醇血症；高胰岛素血症;和肥胖。与人类 MTTP（微粒体甘油三酯转移蛋白）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Cholesterol transfer activity; phosphatidylethanolamine transfer activity; and triglyceride transfer activity. Acts upstream of or within several processes, including Cholesterol homeostasis; lipoprotein transport; and low-density lipoprotein particle remodeling. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in gut; liver; placenta; septum transversum hepatic component; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2022]