2. Gene
  3. Myb - myeloblastosis oncogene Gene

Myb - myeloblastosis oncogene Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: c-myb

基因 ID: 17863 | 基因类型: protein coding

关于 Myb

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to cytokine stimulus; embryonic digestive tract development; and hematopoietic or lymphoid organ development. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study essential thrombocythemia and myelofibrosis. Orthologous to human MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Myb 基因产物(2)

mRNA Protein Name
NM_001198914.1 NP_001185843.1 transcriptional activator Myb isoform 1
NM_010848.3 NP_034978.3 transcriptional activator Myb isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12628004 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12244173 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
12628004 MGI
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
12660151 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12244173 MGI
enables WD40-repeat domain binding IDA
IDA: 通过直接分析推断
16162816 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8302594 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell differentiation IMP
IMP: 通过突变表型推断
17927961 MGI
acts upstream of or within G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
12660151 MGI
acts upstream of or within calcium ion transport IMP
IMP: 通过突变表型推断
12660151 MGI
acts upstream of or within cellular response to interleukin-6 IDA
IDA: 通过直接分析推断
16162816 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
acts upstream of or within embryonic digestive tract development IMP
IMP: 通过突变表型推断
10523863 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: 通过突变表型推断
17927961 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
10523863 MGI
acts upstream of or within myeloid cell differentiation IMP
IMP: 通过突变表型推断
19360001 MGI
involved in positive regulation of transcription by RNA polymerase II EXP
EXP: 通过实验结果推断
11792321 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12244173 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15094381 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12628004 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
12660151 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
10523863 MGI
acts upstream of or within spleen development IMP
IMP: 通过突变表型推断
19360001 MGI
acts upstream of or within stem cell division IMP
IMP: 通过突变表型推断
19360001 MGI
acts upstream of or within thymus development IMP
IMP: 通过突变表型推断
17927961 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex EXP
EXP: 通过实验结果推断
11792321 MGI
located in cytosol IDA
IDA: 通过直接分析推断
16162816 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8302594 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcriptional activator Myb

gag-myb protein

myb proto-oncogene protein

myeloblastosis proto-oncogene product

proto-oncogene c-Myb

tumor-specific myb protein

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-108634 Apafant Antagonist 99.96% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10238 MYBMIM Inducer 99.44% 否
HY-108634S Apafant-d8 / 否
HY-RS08869 MYB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18120 Myb Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24594 Myb Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Myb NCBI NCBI:4602
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