1. Gene
  2. Ndufv1 - NADH:ubiquinone oxidoreductase core subunit V1 Gene

Ndufv1 - NADH:ubiquinone oxidoreductase core subunit V1 Gene

种属: Mus musculus

同用名: CI-51kD

基因 ID: 17995 | 基因类型: protein coding

关于 Ndufv1

功能概要

This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The human ortholog of this protein has been characterized. It has consensus motifs for NADH, flavin mononucleotide, and iron-sulfur binding sites and participates in the oxidation of NADH as part of the dehydrogenase module of complex I. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. [provided by RefSeq, Jun 2013]

Ndufv1 基因产物(1)

mRNA Protein Name
NM_133666.3 NP_598427.1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NADH dehydrogenase (ubiquinone) activity IDA
IDA: 通过直接分析推断
29915388 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23530063 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitochondrial electron transport, NADH to ubiquinone IDA
IDA: 通过直接分析推断
29915388 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of respiratory chain complex I IDA
IDA: 通过直接分析推断
29915388 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

NADH dehydrogenase (ubiquinone) flavoprotein 1

NADH dehydrogenase flavoprotein 1

24 kDa (FP)

NADH-ubiquinone oxidoreductase 51 kDa subunit

complex I-51kD

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ndufv1 NCBI NCBI:4723