2. Gene
  3. Nek1 - NIMA (never in mitosis gene a)-related expressed kinase 1 Gene

Nek1 - NIMA (never in mitosis gene a)-related expressed kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: kat; D8Ertd790e

基因 ID: 18004 | 基因类型: protein coding

关于 Nek1

功能概要

Enables 14-3-3 protein binding activity. Involved in regulation of DNA damage checkpoint. Acts upstream of or within several processes, including cellular response to DNA damage stimulus; response to ionizing radiation; and spermatogenesis. Located in centrosome and nucleus. Is expressed in several structures, including central nervous system; ganglia; gonad; lung; and spleen. Used to study autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asphyxiating thoracic dystrophy; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nek1 基因产物(9)

mRNA Protein Name
NM_001293637.1 NP_001280566.1 serine/threonine-protein kinase Nek1 isoform 1
NM_001293638.1 NP_001280567.1 serine/threonine-protein kinase Nek1 isoform 2
NM_001293639.1 NP_001280568.1 serine/threonine-protein kinase Nek1 isoform 4
NM_001414226.1 NP_001401155.1 serine/threonine-protein kinase Nek1 isoform 5
NM_001414227.1 NP_001401156.1 serine/threonine-protein kinase Nek1 isoform 6
NM_001414228.1 NP_001401157.1 serine/threonine-protein kinase Nek1 isoform 7
NM_001414229.1 NP_001401158.1 serine/threonine-protein kinase Nek1 isoform 8
NM_001414230.1 NP_001401159.1 serine/threonine-protein kinase Nek1 isoform 9
NM_175089.4 NP_780298.2 serine/threonine-protein kinase Nek1 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 14-3-3 protein binding IDA
IDA: 通过直接分析推断
28235073 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
15604234 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
10618398 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
10618398 MGI
involved in regulation of DNA damage checkpoint IMP
IMP: 通过突变表型推断
18843199 MGI
acts upstream of or within response to ionizing radiation IMP
IMP: 通过突变表型推断
15604234 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
10618398 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
16267153 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19699716 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/threonine-protein kinase Nek1

NIMA-related kinase 1

NY-REN-55 antigen

Nek1 serine/threonine- and tyrosine-specific protein kinase

kidney, anemia and testis

never in mitosis A-related kinase 1

nimA-related protein kinase 1

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-144425 BSc5367 98.21% 否
HY-103646 CK7 Inhibitor 99.72% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nek1 NCBI NCBI:4750
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