2. Gene
  3. Nf2 - neurofibromin 2 Gene

Nf2 - neurofibromin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: merlin

基因 ID: 18016 | 基因类型: protein coding

关于 Nf2

功能概要

Predicted to enable beta-catenin binding activity; Integrin binding activity; and protein domain specific binding activity. Involved in lens fiber cell differentiation. Acts upstream of or within several processes, including negative regulation of MAPK cascade; negative regulation of protein kinase activity; and nervous system development. Located in several cellular components, including adherens junction; cleavage furrow; and ruffle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study familial meningioma; neurofibromatosis; otitis media; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Apr 2022]

Nf2 基因产物(8)

mRNA Protein Name
NM_001252250.1 NP_001239179.1 merlin isoform 1
NM_001252251.1 NP_001239180.1 merlin isoform 1
NM_001252252.1 NP_001239181.1 merlin isoform 3
NM_001252253.1 NP_001239182.1 merlin isoform 4
NM_001361675.1 NP_001348604.1 merlin isoform 5
NM_001361676.1 NP_001348605.1 merlin isoform 6
NM_001361677.1 NP_001348606.1 merlin isoform 7
NM_010898.4 NP_035028.2 merlin isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12695331 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of MAPK cascade IMP
IMP: 通过突变表型推断
16405865 MGI
acts upstream of Schwann cell proliferation IMP
IMP: 通过突变表型推断
10887156 MGI
acts upstream of or within brain development IMP
IMP: 通过突变表型推断
23863479 MGI
acts upstream of or within cell-cell junction organization IMP
IMP: 通过突变表型推断
12695331 MGI
acts upstream of or within ectoderm development IMP
IMP: 通过突变表型推断
9171370 MGI
acts upstream of or within hippocampus development IMP
IMP: 通过突变表型推断
23863479 MGI
involved in lens fiber cell differentiation IMP
IMP: 通过突变表型推断
20181838 MGI
acts upstream of or within mesoderm formation IMP
IMP: 通过突变表型推断
9171370 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: 通过突变表型推断
16405865 MGI
acts upstream of or within negative regulation of Schwann cell proliferation IMP
IMP: 通过突变表型推断
10887156 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
9553042 MGI
acts upstream of or within negative regulation of osteoblast proliferation IMP
IMP: 通过突变表型推断
10887156 MGI
acts upstream of or within negative regulation of protein kinase activity IDA
IDA: 通过直接分析推断
14580336 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: 通过突变表型推断
16405865 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: 通过突变表型推断
10887156 MGI
acts upstream of osteoblast proliferation IMP
IMP: 通过突变表型推断
10887156 MGI
acts upstream of or within positive regulation of cell differentiation IMP
IMP: 通过突变表型推断
23863479 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12695331 MGI
acts upstream of or within regulation of gliogenesis IMP
IMP: 通过突变表型推断
25433207 MGI
acts upstream of or within regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
23863479 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: 通过突变表型推断
25433207 MGI
acts upstream of or within regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
23863479 MGI
acts upstream of or within regulation of protein stability IMP
IMP: 通过突变表型推断
23863479 MGI
acts upstream of or within regulation of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
25433207 MGI
acts upstream of or within regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
25433207 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IMP
IMP: 通过突变表型推断
12695331 MGI
located in apical part of cell IDA
IDA: 通过直接分析推断
23863479 MGI
located in cell body IDA
IDA: 通过直接分析推断
25433207 MGI
located in cleavage furrow IDA
IDA: 通过直接分析推断
9631655 MGI
located in cortical actin cytoskeleton IDA
IDA: 通过直接分析推断
15467741 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
8547603 MGI
located in cytoskeleton IDA
IDA: 通过直接分析推断
15467741 MGI
located in filopodium IDA
IDA: 通过直接分析推断
9563848 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
9563848 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
25433207 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15133494 MGI
located in ruffle IDA
IDA: 通过直接分析推断
9563848 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

merlin

moesin-ezrin-radixin-like protein

neurofibromatosis 2

schwannomin

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134955 VT103 Inhibitor 99.64% 否
HY-155309 LM-41 Inhibitor 99.82% 否
HY-158342 PROTAC TEAD degrader-1 Degrader 99.82% 否
HY-163644 VT-105 Inhibitor 99.93% 否
HY-155310 AF-2112 Inhibitor 99.82% 否
HY-113821 1-Naphthyl phosphate potassium salt Inhibitor / 否
HY-162012 HC-258 / 否
HY-RS09234 NF2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16884 Nf2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23326 Nf2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nf2 NCBI NCBI:4771
Macaca fascicularis Nf2 NCBI NCBI:102139594
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