2. Gene
  3. Nfatc2 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 Gene

Nfatc2 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NFAT1; Nfatp; NF-ATp; NF-ATc2; NFAT1-D

基因 ID: 18019 | 基因类型: protein coding

关于 Nfatc2

功能概要

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of gene expression. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; myotube cell development; and positive regulation of myoblast fusion. Located in chromatin; cytosol; and nucleus. Part of ribonucleoprotein complex and transcription regulator complex. Is expressed in several structures, including brain; genitourinary system; jaw; spinal cord; and thymus primordium. Orthologous to human NFATC2 (nuclear factor of activated T cells 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc2 基因产物(16)

mRNA Protein Name
NM_001037177.2 NP_001032254.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform b
NM_001037178.2 NP_001032255.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform c
NM_001136073.2 NP_001129545.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform d
NM_001291168.1 NP_001278097.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform e
NM_001291169.1 NP_001278098.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform f
NM_001291170.1 NP_001278099.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform g
NM_001291171.1 NP_001278100.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform h
NM_001291172.1 NP_001278101.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform i
NM_001291173.1 NP_001278102.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform j
NM_001291174.1 NP_001278103.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform k
NM_001291175.1 NP_001278104.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform k
NM_001291176.1 NP_001278105.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform h
NM_001291177.1 NP_001278106.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform g
NM_001291178.1 NP_001278107.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform j
NM_001291179.1 NP_001278108.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform c
NM_010899.3 NP_035029.2 nuclear factor of activated T-cells, cytoplasmic 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
8235597 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15319455 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
24161931 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12453415 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8235597 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
24301466 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8943202 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7650004 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
19752193 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
24301466 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within calcineurin-NFAT signaling cascade IGI
IGI: 通过遗传相互作用推断
18676376 MGI
involved in cartilage development IMP
IMP: 通过突变表型推断
10620601 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: 通过直接分析推断
23259949 MGI
acts upstream of or within cytokine production IDA
IDA: 通过直接分析推断
15790681 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
23259949 MGI
acts upstream of or within lncRNA transcription IMP
IMP: 通过突变表型推断
29475982 MGI
acts upstream of or within myotube cell development IMP
IMP: 通过突变表型推断
18676376 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12453415 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
19752193 MGI
acts upstream of or within positive regulation of myoblast fusion IMP
IMP: 通过突变表型推断
12757709 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8235597 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
24301466 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
24161931 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
24301466 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
24161931 MGI
is active in cytoplasm IDA
IDA: 通过直接分析推断
23259949 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
8668213 MGI
located in cytosol IDA
IDA: 通过直接分析推断
8235597 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
23259949 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8235597 MGI
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
21709260 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
8235597 MGI
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
19561615 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nuclear factor of activated T-cells, cytoplasmic 2

NFAT pre-existing subunit

T-cell transcription factor NFAT1

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09239 NFATC2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-162280 PROTAC BTK Degrader-9 / 否
HY-RS09240 NFATC2IP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19067 Nfatc2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25557 Nfatc2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nfatc2 NCBI NCBI:4773
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