Nfkbib - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Gene

种属: Mus musculus

同用名: IkB; IkBb; ikB-B; IKB-beta; IKappaBbeta; NF-kappa-BIB; I-kappa-B-beta; I(Kappa)B(beta)

关于 Nfkbib

功能概要

This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as Cytokines and Growth Factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]