DPYSL2 - dihydropyrimidinase like 2 Gene

中文名称：二氢嘧啶酶样 2

种属: Homo sapiens

同用名: DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2

基因 ID: 1808 | 基因类型: protein coding

关于 DPYSL2

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,514,031-26,658,175 (from NCBI)

This gene has 8 transcripts (splice variants), 280 orthologues and 5 paralogues. Broad expression in brain (RPKM 146.0), lung (RPKM 48.2) and 15 other tissues.

功能概要

该基因编码塌陷反应介质蛋白家族的一个成员。 Collapsin 反应介质蛋白形成同源和异源四聚体，促进神经元引导、生长和极性。编码的蛋白质促进微管组装，是 Sema3A 介导的生长锥塌陷所必需的，并且还通过与钙通道的相互作用在突触信号传导中发挥作用。该基因与多种神经系统疾病有关，编码蛋白的过度磷酸化可能在阿尔茨海默病的发展中起关键作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 9 月]

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

DPYSL2 基因产物(3)

mRNA	Protein	Name
NM_001197293.3	NP_001184222.1	dihydropyrimidinase-related protein 2 isoform 1
NM_001244604.2	NP_001231533.1	dihydropyrimidinase-related protein 2 isoform 3
NM_001386.6	NP_001377.1	dihydropyrimidinase-related protein 2 isoform 2

DPYSL2 蛋白结构

Amidohydro_1

0
100
200
300
400
500
572 a.a.

蛋白主名

其他名称

dihydropyrimidinase-related protein 2

collapsin response mediator protein hCRMP-2

DPYSL2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DPYSL2	Q16555	DPYSL3	Homo sapiens	Q14195-2	Y2H Prey Pooling	32296183
种属内	DPYSL2	Q16555	DPYSL3	Homo sapiens	Q14195-2	Y2H Array	32296183
种属内	DPYSL2	Q16555	DPYSL3	Homo sapiens	Q8IXW6	Y2H Prey Pooling	25416956
种属内	DPYSL2	Q16555	DPYSL5	Homo sapiens	Q9BPU6	Validated Y2H	25416956
种属内	DPYSL2	Q16555	DPYSL2	Homo sapiens	Q16555	Y2H Prey Pooling	32296183
种属内	DPYSL2	Q16555	DPYSL5	Homo sapiens	Q9BPU6	Validated Y2H	32296183
种属内	DPYSL2	Q16555	DPYSL5	Homo sapiens	Q9BPU6	Y2H Array	25416956
种属内	DPYSL2	Q16555	DPYSL2	Homo sapiens	Q16555	Validated Y2H	32296183
种属内	DPYSL2	Q16555	DPYSL2	Homo sapiens	Q16555	Y2H Array	25416956
种属内	DPYSL2	Q16555	DPYSL5	Homo sapiens	Q9BPU6	Y2H Array	32296183
种属内	DPYSL2	Q16555	DPYSL5	Homo sapiens	Q9BPU6	Y2H Prey Pooling	25416956
种属内	DPYSL2	Q16555	DPYSL2	Homo sapiens	Q16555	Y2H Array	32296183
种属内	DPYSL2	Q16555	DPYSL2	Homo sapiens	Q16555	Y2H Array	29892012
种属内	DPYSL2	Q16555	DPYSL5	Homo sapiens	Q9BPU6	Y2H Prey Pooling	32296183
种属内	DPYSL2	Q16555	DPYSL2	Homo sapiens	Q16555	Y2H	21516116
种属内	DPYSL2	Q16555	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
种属内	DPYSL2	Q16555	DPYSL2	Homo sapiens	Q16555	Y2H Array	31515488
种属内	DPYSL2	Q16555	DPYSL3	Homo sapiens	Q14195	Y2H Array	29892012
种属内	DPYSL2	Q16555	CRMP1	Homo sapiens	Q14194	Y2H Array	32296183
种属内	DPYSL2	Q16555	CRMP1	Homo sapiens	Q14194	Y2H Prey Pooling	32296183
种属内	DPYSL2	Q16555	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
种属内	DPYSL2	Q16555	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
种属内	DPYSL2	Q16555	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	29892012
种属内	DPYSL2	Q16555	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	31515488
种属内	DPYSL2	Q16555	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
种属内	DPYSL2	Q16555	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DPYSL2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71816	DPYSL2 Protein, Human (P.pastoris, His)	Q16555 (M1-G572)	≥95%

DPYSL2 抗体

目录号	产品名	应用	反应物种
HY-P83625	CRMP2 Antibody (YA3370)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03981	DPYSL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18860	Dpysl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25352	Dpysl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DPYSL2	MGD	MGI:1349763
Canis familiaris	DPYSL2	VGNC	VGNC:40083
Bos taurus	DPYSL2	VGNC	VGNC:28195
Rattus norvegicus	DPYSL2	RGD	RGD:2517
Macaca mulatta	DPYSL2	VGNC	VGNC:71984
Felis catus	DPYSL2	VGNC	VGNC:61615
Others	DPYSL2	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DPYSL2 - dihydropyrimidinase like 2 Gene

关于 DPYSL2

功能概要

DPYSL2 基因产物(3)

DPYSL2 蛋白结构

DPYSL2 蛋白互作信息

重组 DPYSL2 蛋白

DPYSL2 抗体

关联疾病

直系同源

热门区域

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DPYSL2 - dihydropyrimidinase like 2 Gene

关于 DPYSL2

功能概要

DPYSL2 基因产物(3)

DPYSL2 蛋白结构

DPYSL2 蛋白互作信息

重组 DPYSL2 蛋白

DPYSL2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z