Mycn - v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived Gene

种属: Mus musculus

同用名: Nmyc; N-myc; Nmyc1; Nmyc-1; c-nmyc; bHLHe37

关于 Mycn

功能概要

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and kinase binding activity. Involved in negative regulation of Reactive Oxygen Species metabolic process and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic digit morphogenesis; negative regulation of astrocyte differentiation; and skeletal system morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]