2. Gene
  3. Numb - NUMB endocytic adaptor protein Gene

Numb - NUMB endocytic adaptor protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Nb

基因 ID: 18222 | 基因类型: protein coding

关于 Numb

功能概要

This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Numb 基因产物(8)

mRNA Protein Name
NM_001136075.3 NP_001129547.1 protein numb homolog isoform 1
NM_001272055.2 NP_001258984.1 protein numb homolog isoform 3
NM_001272056.1 NP_001258985.1 protein numb homolog isoform 4
NM_001411949.1 NP_001398878.1 protein numb homolog isoform 1
NM_001411950.1 NP_001398879.1 protein numb homolog isoform 2
NM_001411951.1 NP_001398880.1 protein numb homolog isoform 4
NM_001411952.1 NP_001398881.1 protein numb homolog isoform 3
NM_010949.3 NP_035079.1 protein numb homolog isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-catenin binding IPI
IPI: 通过物理相互作用推断
17589506 MGI
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
17589506 MGI
enables cadherin binding IPI
IPI: 通过物理相互作用推断
17589506 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11922143 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adherens junction organization IGI
IGI: 通过遗传相互作用推断
17589506 MGI
acts upstream of or within axonogenesis IDA
IDA: 通过直接分析推断
15598981 MGI
acts upstream of or within axonogenesis IMP
IMP: 通过突变表型推断
15598981 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
14687546 MGI
involved in lateral ventricle development IMP
IMP: 通过突变表型推断
17174898 MGI
acts upstream of or within nervous system development IMP
IMP: 通过突变表型推断
10841580 MGI
involved in neuroblast division in subventricular zone IMP
IMP: 通过突变表型推断
17174898 MGI
acts upstream of or within neuroblast proliferation IGI
IGI: 通过遗传相互作用推断
12410312 MGI
involved in positive regulation of neurogenesis IMP
IMP: 通过突变表型推断
12410312 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
26621723 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: 通过表达模式推断
26621723 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
26621723 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
12361975 MGI
NOT located in apical plasma membrane IDA
IDA: 通过直接分析推断
17589506 MGI
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
17589506 MGI
located in clathrin-coated pit IDA
IDA: 通过直接分析推断
26437238 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
22174158 MGI
located in early endosome IDA
IDA: 通过直接分析推断
11782429 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
26621723 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
26621723 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
26621723 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein numb homolog

numb gene homolog

numb homolog

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119734 Gossypolone 96.63% 否
HY-N7013 Hydroxy-Epsilon-Sanshool / 否
HY-N7014 Hydroxyl-​γ-​isosanshool / 否
HY-RS09681 NUMB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19926 Numb Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26428 Numb Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Numb NCBI NCBI:8650
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