2. Gene
  3. Tnfrsf11b - tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Gene

Tnfrsf11b - tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Opg; TR1; OCIF

基因 ID: 18383 | 基因类型: protein coding

关于 Tnfrsf11b

功能概要

Acts upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; lung; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF Receptor Superfamily member 11b). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf11b 基因产物(2)

mRNA Protein Name
NM_001411506.1 NP_001398435.1 tumor necrosis factor receptor superfamily member 11B isoform 2
NM_008764.4 NP_032790.3 tumor necrosis factor receptor superfamily member 11B isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heparan sulfate binding IDA
IDA: 通过直接分析推断
29415886 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23039992 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within extracellular matrix organization IDA
IDA: 通过直接分析推断
18757743 MGI
acts upstream of or within negative regulation of odontogenesis of dentin-containing tooth IDA
IDA: 通过直接分析推断
14981127 MGI
acts upstream of or within negative regulation of osteoclast differentiation IDA
IDA: 通过直接分析推断
29415886 MGI
involved in negative regulation of osteoclast differentiation IDA
IDA: 通过直接分析推断
9168977 MGI
acts upstream of or within negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: 通过直接分析推断
29415886 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular matrix IDA
IDA: 通过直接分析推断
9108485 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 11B

osteoclastogenesis inhibitory factor

osteoprotegerin

重组 Tnfrsf11b 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71017 TNFRSF11B/OPG Protein, Mouse (HEK293, His) O08712 (E22-L401) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14802 TNFRSF11B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17571 Tnfrsf11b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24031 Tnfrsf11b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tnfrsf11b NCBI NCBI:4982
Macaca mulatta Tnfrsf11b NCBI NCBI:701850
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