2. Gene
  3. DTYMK - deoxythymidylate kinase Gene

DTYMK - deoxythymidylate kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脱氧胸苷酸激酶

种属: Homo sapiens

同用名: CDC8; TMPK; TYMK; CONPM; PP3731

基因 ID: 1841 | 基因类型: protein coding

关于 DTYMK

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,675,747-241,686,815 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 9.1), lymph node (RPKM 8.0) and 25 other tissues.

功能概要

启用胸苷酸激酶活性。预计参与 dTDP 生物合成过程； dTTP 生物合成过程；和 dUDP 生物合成过程。预计在细胞对生长因子刺激和核苷酸生物合成过程的反应的上游或内部起作用。预测位于线粒体膜间隙和线粒体基质中。预计在胞质溶胶中有活性；线粒体；和核。 [由基因组资源联盟提供，2022 年 4 月]

Enables thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to act upstream of or within cellular response to growth factor stimulus and nucleotide biosynthetic process. Predicted to be located in mitochondrial intermembrane space and mitochondrial matrix. Predicted to be active in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DTYMK 基因产物(6)

mRNA Protein Name
NM_001165031.2 NP_001158503.1 thymidylate kinase isoform 2
NM_001320902.2 NP_001307831.1 thymidylate kinase isoform 3
NM_001320903.2 NP_001307832.1 thymidylate kinase isoform 4
NM_001320904.2 NP_001307833.1 thymidylate kinase isoform 5
NM_001320905.2 NP_001307834.1 thymidylate kinase isoform 6
NM_012145.4 NP_036277.2 thymidylate kinase isoform 1

DTYMK 蛋白结构

Thymidylate_kin

Thymidylate_kin: Thymidylate kinase (11 - 191)

  • 0
  • 100
  • 200
  • 212 a.a.
蛋白主名 其他名称

thymidylate kinase

dTMP kinase

重组 DTYMK 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70012 Thymidylate Protein, Human (HEK293, His) P23919 (M1-K212) ≥95%

关联疾病

疾病名称 别名
Neurodegeneration, Childhood-Onset, With Progressive Microcephaly

CONPM
Developmental And Epileptic Encephalopathy 50

DEE50

Epileptic Encephalopathy, Early Infantile, 50

Eiee50

Developmental And Epileptic Encephalopathy, 50

Congenital Disorder Of Glycosylation, Type Iz, Formerly

Cdg1z, Formerly

Carbohydrate Deficient Glycoprotein Syndrome Type Iz

Cdg Syndrome Type Iz

Cdg-Iz

Congenital Disorder Of Glycosylation Type 1z

Early Infantile Epileptic Encephalopathy 50

Cdg1z

Congenital Disorder Of Glycosylation 1z

Encephalopathy, Epileptic, Early Infantile,, Type 50
Submandibular Adenitis

Submandibular Lymphadenitis
Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB
Disease By Infectious Agent

Infectious Disease

Infectious Diseases
Mitochondrial Dna Depletion Syndrome

Mtdna Depletion Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-158820 Cosdosiran / 否
HY-158820A Cosdosiran sodium / 否
HY-E70364 IgdE protease / 否
HY-RS04043 DTYMK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DTYMK VGNC VGNC:28240
Mus musculus DTYMK MGD MGI:108396
Felis catus DTYMK VGNC VGNC:61652
Macaca mulatta DTYMK VGNC VGNC:72008
Canis familiaris DTYMK VGNC VGNC:59076
Rattus norvegicus DTYMK RGD RGD:1309614
Others DTYMK NCBI
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